Українська English

ISSN 2522-9028 (Print)
ISSN 2522-9036 (Online)
DOI: https://doi.org/10.15407/fz

Fiziologichnyi Zhurnal

is a scientific journal issued by the

Bogomoletz Institute of Physiology
National Academy of Sciences of Ukraine

Editor-in-chief: V.F. Sagach

The journal was founded in 1955 as
1955 – 1977 "Fiziolohichnyi zhurnal" (ISSN 0015 – 3311)
1978 – 1993 "Fiziologicheskii zhurnal" (ISSN 0201 – 8489)
1994 – 2016 "Fiziolohichnyi zhurnal" (ISSN 0201 – 8489)
2017 – "Fiziolohichnyi zhurnal" (ISSN 2522-9028)

Fiziol. Zh. 2010; 56(1): 87-90


Cytokine profile in dynamics of acute period of ischemic stroke

A.S. Kost, B.D. Lutsyk, L.Ye. Lapovets, M.S. Bilobrin

    Danylo Galytskyi Lviv Nartional University, Ukraine
DOI: https://doi.org/10.15407/fz56.01.087


Abstract

The changes in dynamics of pro- and antiinflammatory cytokines in acute period of ischemic stroke in 39 patients aged from 46 to 80 with ischemic stroke were investigated. It was shown that the local inflammation development in acute period of ischemic stroke is a consequence of disbalance in the system cytokines regulation and depends on the degree of neurologic disturbances. The exspression of inflammatory reaction depends on the increased activity of proinflammatory cytokines and the insufficient productivity of antiinflamma-tory cytokines.

Keywords: ischemic stroke, inflammatory reaction, cytokines.

References

  1. Beridze M.S., Urusadze I.T., Shakarashvili P.P. Mechanisms of delayed neuronal death in acute cerebral ischemia in an experiment . Stroke. 2001. N 3. P. 35-40.
  2.  
  3. Vasilenko E., Yarosh O., Ostapchenko L. Stroke: current views on the problem . Visn. HAH of Ukraine. 2007. N 5. P. 29-34.
  4.  
  5. Malakhov VA, Potapov OO, Lichko B.C. Liquor-logical changes in ischemic stroke . Visn. SSU 2006. N 8. P. 73-80.
  6.  
  7. Mishchenko TS Epidemiology of cerebrovascular disease in Ukraine in 2007 . Vascular diseases of the brain. 2008. N 2. P. 3-7.
  8.  
  9. Skvortsova VI, Sherstnev VV, December MA The role of autoimmune mechanisms in ischemia damaging action . Stroke. 2001. N 1. P. 46-52.
  10.  
  11. Cherenko TM Markers of inflammation and change in cerebral blood flow in patients with different clinical course of ischemic stroke . Heart and vessels. 2004. N 2. P. 39-47.
  12.  
  13. Adams H.P., Adams R.J., Brott T. et al. Guidelines for the early management of patient with ischemic stroke: A scientific statement from the Stroke Council of the American Stroke Association . Stroke. 2003. 34, N 4. P. 1056-1083. CrossRef PubMed
  14.  
  15. Bartko D., Lesicky O.,Buc M. Cerebral infarct and the immune respons . Bratisl. Lek. Listy. 1997. N 98. P. 321-329.
  16.  
  17. Liu T., Clark R.K., McDonnell P.C. et al. Tumor ne­crosis factor-alpha expression in ischemic neurons . Stroke. 1994. N 25. P. 1481-1488. CrossRef PubMed
  18.  
  19. Liu T., McDonnell P.C, Young P.R. et al. Interleukin-1 beta mRNA expression in ischemic rat cortex . Ibid. 1993. N 24. P. 1746-1750. CrossRef PubMed
  20.  
  21. Odderson I.R. The National Institutes of Health Stroke Scale and its importance in acute stroke management . Physiol. Med. Rehabil. Clin. N. Am. 1999. 10, N 4. P. 787-800. CrossRef  
  22. Tan K.T., Lip G.Y., Blann A.D. Post-stroke inflamma­tory response: effects of stroke evolution and outcome . . Curr. Atheroscler. Rep. 2003. N 5. P. 245-251. CrossRef PubMed
  23.  
  24. Vila N., Castillo J., Davalos A. et al. Proinflammatory cytokines and early neurological worsening in ischemic stroke . Stroke. 2000. 31,N 10. P. 2325-2329. CrossRef PubMed
  25.  
  26. Wang X.,Yue T.L., Young P.R. et al. Expression of . interleukin-6, c-fox, and zif268 mRNAs in rat ischemic cortex . J.Cereb. Blood Flow Metab. 1995. N 5. P. 166-171. CrossRef PubMed

© National Academy of Sciences of Ukraine, Bogomoletz Institute of Physiology, 2014-2024.