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ISSN 2522-9028 (Print)
ISSN 2522-9036 (Online)
DOI: https://doi.org/10.15407/fz

Fiziologichnyi Zhurnal

is a scientific journal issued by the

Bogomoletz Institute of Physiology
National Academy of Sciences of Ukraine

Editor-in-chief: V.F. Sagach

The journal was founded in 1955 as
1955 – 1977 "Fiziolohichnyi zhurnal" (ISSN 0015 – 3311)
1978 – 1993 "Fiziologicheskii zhurnal" (ISSN 0201 – 8489)
1994 – 2016 "Fiziolohichnyi zhurnal" (ISSN 0201 – 8489)
2017 – "Fiziolohichnyi zhurnal" (ISSN 2522-9028)

Fiziol. Zh. 2001; 47(1): 3-8

Spontaneous transient outward currentsin smooth muscle cells of the rat tail artery

V. L. Reznikov, M. F Shuba

    A. A. Bogomoletz Institute of Physiology,National Academy of Sciences of Ukraine, Kiev



Abstract

V. L. Reznikov, M. F Shuba SPONTANEOUS TRANSIENT OUTWARD CURRENTS IN SMOOTH MUSCLE CELLS OF THE RAT TAIL ARTERY Spontaneous transient outward currents (STOCs) were studied in the rat tail artery smooth muscle cells using standard patch-clamp recording techniques in the wholecell configuration. STOCs evoked by membrane depolarization from .30 to 20 mV varied in size from 50 to 1000 pA, their amplitude increased with membrane depolarization. These currents were inhibited by 1 mM TEA+. Both the frequency and the transferred charge (Q) were decreased in the absence of the extracellular Ca2+ or in the presence of the selective blocker of voltage-gated L-type Ca2+ channels nifedipine. Application of caffeine at 1 mM increased both Q and the frequency of STOCs generation. These results indicate that STOCs are carried by large conductance Ca2+-dependent K+ channels and Ca2+ influx plays an important role in their activation. A. A. Bogomoletz Institute of Physiology, National Academy of Sciences of Ukraine, Kiev

Full text: (PDF, in Ukrainian)

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