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ISSN 2522-9028 (Print)
ISSN 2522-9036 (Online)
DOI: https://doi.org/10.15407/fz

Fiziologichnyi Zhurnal

is a scientific journal issued by the

Bogomoletz Institute of Physiology
National Academy of Sciences of Ukraine

Editor-in-chief: V.F. Sagach

The journal was founded in 1955 as
1955 – 1977 "Fiziolohichnyi zhurnal" (ISSN 0015 – 3311)
1978 – 1993 "Fiziologicheskii zhurnal" (ISSN 0201 – 8489)
1994 – 2016 "Fiziolohichnyi zhurnal" (ISSN 0201 – 8489)
2017 – "Fiziolohichnyi zhurnal" (ISSN 2522-9028)

Fiziol. Zh. 2010; 56(1): 30-40


THE ASSOCIATION OF -1082A→G POLYMORPHISM OF IL-10 AND (-308A→G) POLYMORPHISM OF TNFα GENES WITH BONE DENSITY IN ELDERLY WOMEN

І.М. Pishel, О.О. Yevtushenko, Yu.І. Leonov, N.V. Grygoryeva, Т.V. Orlyk, D.V.Shytikov, V.V. Povoroznyuk, G.М. Butenko.

    Institute of Gerontology of AMS of Ukraine, Kyiv, Ukraine
DOI: https://doi.org/10.15407/fz56.01.030

Abstract

We studied the association between disturbances of structure and function in bone tissue and (-1082A -> G) polymorphism of IL-10 and (-308A -> G) polymorphism of TNFб genes. SNP-polymerase cyclic reaction was used. The study failed to find significant influence of (-308A -> G) TNF6 polymorphism on the development of bone tissue pathology in postmenopausal women. The patients with AA genotype of -1082A/G IL-10 gene have significantly lower indices of bone density comparing with G allele carriers (GG/AG). This association remained true both for bone tissue density of whole body, and for sepa­rate parts of skeleton: lumbar spine, femur neck, Ward zone of hip bone. Our study indicates that (-308A -> G) polymorphism of TNFa gene is not associated with structural-functional changes in bone tissue in Ukrainian population. However, there is strong evidence that women who carries the AA geno­type of -1082A/G polymorphism of IL-10 gene have signifi­cantly lower bone tissue density. This indicates the potentialfor predictive genetic testing of osteoporosis risk. Analyses of gene combination IL-10 -1082G/G and TNFa -308G/G («anti­inflammatory genotype») did not show any significant asso­ciation of this genotype with bone tissue characteristics, which shows low predictive value of this combination for diagnos­tics of structural-functional state of bone tissue.

Keywords: gene polymorphisms, bone tissue, aging, IL-10,TNF

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