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ISSN 2522-9028 (Print)
ISSN 2522-9036 (Online)

Fiziologichnyi Zhurnal

is a scientific journal issued by the

Bogomoletz Institute of Physiology
National Academy of Sciences of Ukraine

Editor-in-chief: V.F. Sagach

The journal was founded in 1955 as
1955 – 1977 "Fiziolohichnyi zhurnal" (ISSN 0015 – 3311)
1978 – 1993 "Fiziologicheskii zhurnal" (ISSN 0201 – 8489)
1994 – 2016 "Fiziolohichnyi zhurnal" (ISSN 0201 – 8489)
2017 – "Fiziolohichnyi zhurnal" (ISSN 2522-9028)

Fiziol. Zh. 2010; 56(1): 30-40


І.М. Pishel, О.О. Yevtushenko, Yu.І. Leonov, N.V. Grygoryeva, Т.V. Orlyk, D.V.Shytikov, V.V. Povoroznyuk, G.М. Butenko.

    Institute of Gerontology of AMS of Ukraine, Kyiv, Ukraine


We studied the association between disturbances of structure and function in bone tissue and (-1082A -> G) polymorphism of IL-10 and (-308A -> G) polymorphism of TNFб genes. SNP-polymerase cyclic reaction was used. The study failed to find significant influence of (-308A -> G) TNF6 polymorphism on the development of bone tissue pathology in postmenopausal women. The patients with AA genotype of -1082A/G IL-10 gene have significantly lower indices of bone density comparing with G allele carriers (GG/AG). This association remained true both for bone tissue density of whole body, and for sepa­rate parts of skeleton: lumbar spine, femur neck, Ward zone of hip bone. Our study indicates that (-308A -> G) polymorphism of TNFa gene is not associated with structural-functional changes in bone tissue in Ukrainian population. However, there is strong evidence that women who carries the AA geno­type of -1082A/G polymorphism of IL-10 gene have signifi­cantly lower bone tissue density. This indicates the potentialfor predictive genetic testing of osteoporosis risk. Analyses of gene combination IL-10 -1082G/G and TNFa -308G/G («anti­inflammatory genotype») did not show any significant asso­ciation of this genotype with bone tissue characteristics, which shows low predictive value of this combination for diagnos­tics of structural-functional state of bone tissue.

Keywords: gene polymorphisms, bone tissue, aging, IL-10,TNF


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