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ISSN 2522-9028 (Print)
ISSN 2522-9036 (Online)
DOI: https://doi.org/10.15407/fz

Fiziologichnyi Zhurnal

is a scientific journal issued by the

Bogomoletz Institute of Physiology
National Academy of Sciences of Ukraine

Editor-in-chief: V.F. Sagach

The journal was founded in 1955 as
1955 – 1977 "Fiziolohichnyi zhurnal" (ISSN 0015 – 3311)
1978 – 1993 "Fiziologicheskii zhurnal" (ISSN 0201 – 8489)
1994 – 2016 "Fiziolohichnyi zhurnal" (ISSN 0201 – 8489)
2017 – "Fiziolohichnyi zhurnal" (ISSN 2522-9028)

Fiziol. Zh. 2010; 56(1): 22-29


Influence of endothelial nitric oxide synthase T-786→C-promoter polymorphism on integral parameters of functional condition of arterial vessels

A.N. Parkhomenko, Ya.M. Lutay, V.E. Dosenko,V.L. Gurianova, A.A. Moibenko, A.Skarzevskiy.

  1. National Scientific Center «M.D. Strazhesko Institute ofCardiology”, Medical Academy of Sciences of Ukraine, Kyiv, Ukraine;
  2. O.O.Bogomoletz Institute of Physiology, National Academyof Sciences of Ukraine, Kyiv, Ukraine


Abstract

Frequency of eNOS T786->C promoter polymorphism in 325 patients with acute coronary syndrome and 104 control per­sons and influence of this polymorphism on reactive hyper­emia and arterial stiffness were determined. Interrelation be­tween T/T homozygous, T/C heterozygous and C/C homozygous was 42,5%, 41,2% and 16,3%, correspondingly (in control - 40,4%, 53,8% and 5,8%; P<0.01 by X2-test). Higher degree of brachial arteries diameter increase in response to ischemia was estimated in patients with T/T genotype: 8,03 ± 0,71% compared to 5,55 ± 0,92 % in Т/С (P<0.05) and 5,30 ± 1,21 % in C/C genotypes (P<0.05). Speed of pulse wave spreading on carotid-radial and carotid-femoral arteries segments was also depended on patients genotype: in T/T genotype was 9,10 ± 0,15 and 8,68 ± 0,26 correspondingly, in T/C - 9,38 ± 0,18 and 8,74 ± 0,21, and in C/C carriers - 9,71 ± 0,22 and 10,02 ± 0,71 (P<0.05). Thus, the data obtained indi­cate on significant influence of T786->C polymorphism on integral parameters of functional condition of arterial vessels.

Keywords: allelic polymorphism, endothelial NO-synthase,endothelial dysfunction, speed of pulse wave arrival frequency,acute coronary syndrome.

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