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ISSN 2522-9028 (Print)
ISSN 2522-9036 (Online)

Fiziologichnyi Zhurnal

is a scientific journal issued by the

Bogomoletz Institute of Physiology
National Academy of Sciences of Ukraine

Editor-in-chief: V.F. Sagach

The journal was founded in 1955 as
1955 – 1977 "Fiziolohichnyi zhurnal" (ISSN 0015 – 3311)
1978 – 1993 "Fiziologicheskii zhurnal" (ISSN 0201 – 8489)
1994 – 2016 "Fiziolohichnyi zhurnal" (ISSN 0201 – 8489)
2017 – "Fiziolohichnyi zhurnal" (ISSN 2522-9028)

Fiziol. Zh. 2010; 56(1): 3-12

Age-dependence of alterations in nitricoxide synthesis in cardiovascularsystem during adaptation to physicaltraining

O.V.Bazilyuk, A.V.Kotsuruba, L.G.Stepanenco,S.A.Talanow, Yu.P.Korkach, V.F.Sagach.

  1. O.O. Bogomolets Institute of physiology National Academy of Science of Ukraine, Kyiv, Ukraine
  2. A.V. Palladin Institute of Biochemistry National Academy of Science of Ukraine, Kyiv, Ukraine


In aorta and plasma of trained and control non-trained adult and aging rats we studied the features of NO syn­thesis, L-arginin methabilism, oxidative methabolism, endothelium-dependent vasodilation of thoracic aorta during adaptation to physical training (swimming). Our results show age-dependent effects of training : in aorta and plasma we observed 1) the activation of both sal­vage (by nitratereductase + nitritereductase reduction of nitrate- and nitrite-anions) and de novo (L-arginine oxidation by NOS) pathways of nitric oxide synsesis and (2) an increase in nitric oxide bioavailability in train­ing rats, (3) a profound decrease in arginase activity and, as a result, a partial restoration of endothelium-depen-dent vasodilation. We conclude that physical training (preconditioning) is an effective tool of non-medicament correction of age-dependent endothelial dysfunction. Salvage/de novo ratio degree can be a potent biochemical marker of training effectiveness in sportsmen.

Keywords: nitric oxide, vascular tone, endothelium, precondi-tion, training, aging


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