Українська Русский English

ISSN 2522-9028 (Print)
ISSN 2522-9036 (Online)
DOI: https://doi.org/10.15407/fz

Fiziologichnyi Zhurnal

is a scientific journal issued by the

Bogomoletz Institute of Physiology
National Academy of Sciences of Ukraine

Editor-in-chief: V.F. Sagach

The journal was founded in 1955 as
1955 – 1977 "Fiziolohichnyi zhurnal" (ISSN 0015 – 3311)
1978 – 1993 "Fiziologicheskii zhurnal" (ISSN 0201 – 8489)
1994 – 2016 "Fiziolohichnyi zhurnal" (ISSN 0201 – 8489)
2017 – "Fiziolohichnyi zhurnal" (ISSN 2522-9028)

Fiziol. Zh. 2010; 56(1): 3-12


Age-dependence of alterations in nitricoxide synthesis in cardiovascularsystem during adaptation to physicaltraining

O.V.Bazilyuk, A.V.Kotsuruba, L.G.Stepanenco,S.A.Talanow, Yu.P.Korkach, V.F.Sagach.

  1. O.O. Bogomolets Institute of physiology National Academy of Science of Ukraine, Kyiv, Ukraine
  2. A.V. Palladin Institute of Biochemistry National Academy of Science of Ukraine, Kyiv, Ukraine
DOI: https://doi.org/10.15407/fz56.01.003

Abstract

In aorta and plasma of trained and control non-trained adult and aging rats we studied the features of NO syn­thesis, L-arginin methabilism, oxidative methabolism, endothelium-dependent vasodilation of thoracic aorta during adaptation to physical training (swimming). Our results show age-dependent effects of training : in aorta and plasma we observed 1) the activation of both sal­vage (by nitratereductase + nitritereductase reduction of nitrate- and nitrite-anions) and de novo (L-arginine oxidation by NOS) pathways of nitric oxide synsesis and (2) an increase in nitric oxide bioavailability in train­ing rats, (3) a profound decrease in arginase activity and, as a result, a partial restoration of endothelium-depen-dent vasodilation. We conclude that physical training (preconditioning) is an effective tool of non-medicament correction of age-dependent endothelial dysfunction. Salvage/de novo ratio degree can be a potent biochemical marker of training effectiveness in sportsmen.

Keywords: nitric oxide, vascular tone, endothelium, precondi-tion, training, aging

References

  1. Amosova KM, Kotsyuruba AV, Zadorin EM and others. State of NO-system in blood platelets of patients with idiopathic pulmonary hypertension and its changes in the conditions of treatment with calcium channel blocker diltiazem . Supplement. NAS of Ukraine 2007, N 8. P. 183-189.
  2.  
  3. Korkach YP, Kotsyuruba AV, Prysyazhnaya OD etc. NO-Dependent Ways of Implementing the Protective Effect of Ecdysterone on the Heart and Vessels in Streptocotocin-Induced Diabetes in Rats . Fiziol zh.  2007 53, N 3. P. 3-8.
  4.  
  5. Kurgalyuk N., M., Kotsyuruba AV, Sagach V.F. Effect of exogenous Krebs cycle substrates on NO synthesis in acute hypoxia . Fiziol zh.  2005 51, N 4. P. 20-28.
  6.  
  7. Prysyazhnaya OD, Kotsyuruba AV, Tkachenko MM, Sagach VF Effect of enalapril on endothelium-dependent contractile reactions and oxygen cost of smooth muscle in experimental diabetes . Fiziol zh.  2007 53, N 1. P. 3-10.
  8.  
  9. Prysyazhnaya OD, Kotsyuruba AV, Talanov CO., Sagach VF Normalizing effect of integral hypoxic training on endothelial function in experimental diabetes mellitus . Fiziol zh. 2007, 53, N 2 P. 3-7.
  10.  
  11. Sagach VF, Kotsyuruba AV, Basiluk OV etc. Inhibitors of the arginase pathway of L-arginine metabolism as a new class of antihypertensive compounds: effect of urea on lipid oxidative metabolism and vascular tone in hypertension . Fiziol zh.  2001 47, N 5. P. 3-11.
  12.  
  13. Sagach VF, Rudik OV, Vavilova GL etc. Melatonin Restores Ischemic Tolerance and Reduces Sensitivity to Mitochondrial Pore Opening (MRI) in the Heart of Old Rats . Fiziol zh.  2006 52, N 3. P. 3-14.
  14.  
  15. Sagach VF, Basiluk OV, Stepanenko LG and. others Effect of enalapril on nitric oxide synthesis, oxidative metabolism and vascular tone in old rats . Fiziol zh.  2007 53, N 4. P.15-26.
  16.  
  17. Sagach VF, Korkach YP, Kotsyuruba AV etc. Inhibition of mitochondrial pore opening by ecdysterone in the heart of old rats . Fiziol zh.  2008 54, N 4. C. 3-10.
  18.  
  19. Sagach VF, Korkach YP, Kotsyuruba AV, Prysyazhnaya OD Inhibition of oxidative and nitrosative stress as a mechanism of cardio- and vasoprotective action of ecdysterone under experimental sugar diabetics . Ibid 2008 54, N 5. C. 46-54.
  20.  
  21. Tkachenko MM, Sagach VF, Kotsyuruba AV etc. Endothelium-dependent contractile responses of vascular smooth muscle and the content of free oxygen radicals in rats as they age . Fiziol zh.  2002 48, N 4. P. 3-13.
  22.  
  23. Tkachenko MM, Sagach VF, Kotsyuruba AV etc. Age peculiarities of changes in contractile reactions and content of free oxygen radicals and nitric oxide metabolites in BALB . c mice under conditions of being in the exclusion zone . Fiziol zh.  2005 51, N 3. P. 32-41.
  24.  
  25. Tkachenko MM, Sagach VF, Kotsyuruba AV etc. Influence of small doses of radiation on vascular reactivity and oxidative metabolism of oxygen and nitrogen in the cardiovascular system . Fiziol zh. . 2007 13, N 1. P. 20-32.
  26.  
  27. Maiorana B., Driseoll A., Tayler R., Green D. Exercise and the nitric oxide vasodilator system.Sports Med. 2003. 33,N 7. P.1013-1035. CrossRef PubMed
  28.  
  29. Pedersen B.K., Febbraio M.A. Muscle as an endocrine organ: focus on muscle-derived interleukin-6. Physiol. Rev. 2008 Oct;88(4):1379-406. CrossRef PubMed
  30.  
  31. Soloviev A.I., Stefanov A.V., Bazilyuk O.V., Sagach V.F. Phospholipid vesicles (liposomes) restore endothelium-dependent cholinergic relaxation in thoracic aorta from spontaneously hypertensive rats . J. Hypertension. 1993. 11. P.623-627. CrossRef PubMed
  32.  
  33. Strensberg A., Keller C, Hillig T. et. al. Nitric oxide production is a proximal signaling event controlling exercise-induced mRNA expression in skeletal muscle. FASEB J. 2007. 21, N 11. P.2683-2694. CrossRef PubMed
  34.  
  35. Sun C.M. W., Zhang M.-F., Gu J. et. al. Effects of different levels of exercise volume on endothelium-dependent vasodilatation: roles of nitric oxide synthase and heme oxygenase. Hypertens Res. 2008. 31, N 5. P.805-816. CrossRef PubMed
  36.  
  37. Tanabe T., Maeda S., Miyauchi T. et.al. Exercise training improves ageing-induced decrease in eNOS expression of the aorta .Acta Physiol. Scand. 2003. May.178 (1). P.3-10. CrossRef PubMed
  38.  
  39. Tatchum-Talom R., Schulz R. et. al Upregulation of neuronal nitric oxide synthase in skeletal muscle by swim training .Amer. J. Physiol. Heart Circulat. Physiol. 2000. Oct.279 (4). H1757-H1766. CrossRef PubMed

© National Academy of Sciences of Ukraine, Bogomoletz Institute of Physiology, 2014-2020.