Українська Русский English

ISSN 2522-9028 (Print)
ISSN 2522-9036 (Online)

Fiziologichnyi Zhurnal

is a scientific journal issued by the

Bogomoletz Institute of Physiology
National Academy of Sciences of Ukraine

Editor-in-chief: V.F. Sagach

The journal was founded in 1955 as
1955 – 1977 "Fiziolohichnyi zhurnal" (ISSN 0015 – 3311)
1978 – 1993 "Fiziologicheskii zhurnal" (ISSN 0201 – 8489)
1994 – 2016 "Fiziolohichnyi zhurnal" (ISSN 0201 – 8489)
2017 – "Fiziolohichnyi zhurnal" (ISSN 2522-9028)

Fiziol. Zh. 2009; 55(6): 69-74

Effects of cardioelectrostimulation and chemical reagents on autonomicnervous regulation of heart rate

R.vaiciulyte, R.lekas, G.civinskiene, A.laukeviciene, J.bernatoniene, V. Giedrimas, J.andriuskevicius

    Ин-т кардиологии; Ин-т биомед. исследований;Каунас. мед. ун-т


The aim of the study was to evaluate the peculiarities of heart rate variability and autonomic nervous system regulation and to predict the changes in sinus rhythm after successful medical or electrical correction. 72 patients with atrial fibrillation be­fore and after its correction have been monitored. Atrial fibril­lation during the first month after cardioversion occurred in 26,3 % of patients. Data analysis using computerized heart rhythm analysis showed a decreased heart rate variability in patients during atrial fibrillation and increased heart rate vari­ability. These parameters are the markers which characterize the sinus rhythm maintenance.


  1. Akyurek O., Diker E., Guldal M., Oral D. Predictive value of heart rate variability for the reccurrence of chronic atrial fibrillation after electrical cardioversion // Clin Cardiol. - 2003. - April; 26(4). - P.196-200.
  2. ACC/AHA/ESC 2006 guidelines for the management of patients with atrial fibrillation - execuvite summary. A report of the American College of Cardiology/American Heart Associaton Task Force on practice guidelines and the European Society of Cardiology Committee for Prac­tice Guidelines (Writing Committee to Revise the Guide­lines for the Management of Patients with Atrial Fibrilla­tion)// Eur. Heart. J. - 2006. - 27. - P.1979-2030.
  3. Coumel P., Thomas O. Drug therapy for prevention of atrial fibrillation // Amer. J. Cardiol. - 1996. - 77. -P.3A-9A.
  4. Elvan A., Pride H.P., Eble J.N., Zipes D.P. Radio-frequency catheter ablation of the reduces inducibility and duration of atrial fibrillation in dogs // Circulation. -1995. - 91. -P.2235-2244.
  5. Feinberg W.M., Cornel E.S., Nightingale S.D. et al. For the Stroke Prevention in Atrial Fibrillation Investi­gators. Relationship between prothrombin activation fragment F1.2 and international normalized ratio in patients with atrial fibrillation // Stroke. - 1997. - 28. -P.1101-1106.
  6. Klingenheben T., Gronefeld G., Li Y.G., Hohnloser SH. Heart rate variability to assess changes in cardiac vagal modulation prior to the conset of paroxysmal atrial fibrillation in patients with and without structural heart disease// ANE. - 1999. - 4. - P.16-26.
  7. Lombardi M., Colombo A., Basilico B. et al. Heart rate variability and early reccurrence of atrial fibrillation after electrical cardioversion // Electrophysiology. -20001. - 37. -P.157-162.
  8. Ostranderld J.R., Brandt R.L., Kjelsberg M.O., Epstein F.H. Electrocardiographic findings among the adult population of total natural community // Circulation. -1965. - 31. -P.888-898.
  9. 9. Paskeviciute R, Zemaityte D, Varoneckas G. Poincare plots in diagnostic of atrial fibrillation and flutter and prediction of maintenance of sinus rhythm after conversion // Kardiol.os Sem. - 2000. - 6. - P.42-44.
  10. 10. Psaty B.M., Manolio T.A., Kuller L.H. et al. Incidence of and risk factors for atrial fibrillation in older adults// Circulation. - 1997. - 96. - P.2455-2461.
  11. Stein K.M., Borer J.S. Variability of the ventricular response in atrial fibrillation and prognosis in chronic nonischemic mitral regurgitation // Amer. J. Cardiol. -1994. - 74. -P. 906-911.
  12. Timmermans C, Rodriguez L.M. Effects of electrode length on atrial fibrillation thresholds // J. Cardiovasc. Electrophysiol. - 1998. - 9. - P.582-587.
  13. Vaiciulyte R., Peciuliene I., Sokolovas V., Pretkelyte A. Peculiaritys of heart rate variability in patients dur­ing atrial fibrillation and after conversion // Medicina. - 2001. - 37. -P. 1641-1644.
  14. Vaiciulyte R., Kaukenas J. Диагностика мерцательной аритмии методом компьютерного анализа ритмо-грамм (Computer diagnosis of the atrial fibrillation by the method of rhythmography). Теория и практика автоматизации кардиологических исследований. - В кн.: Материалы симпозиума специалистов стран-членов СЭВ. –Каунас, 1990. - Р. 241.
  15. Wiegand U.K., Bonnemeier H. Heart rate variability pre­ceding the onset of atrial fibrillation // Herz. - 2001. - 26. -P.49-54.

© National Academy of Sciences of Ukraine, Bogomoletz Institute of Physiology, 2014-2019.