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ISSN 2522-9028 (Print)
ISSN 2522-9036 (Online)
DOI: https://doi.org/10.15407/fz

Fiziologichnyi Zhurnal

is a scientific journal issued by the

Bogomoletz Institute of Physiology
National Academy of Sciences of Ukraine

Editor-in-chief: V.F. Sagach

The journal was founded in 1955 as
1955 – 1977 "Fiziolohichnyi zhurnal" (ISSN 0015 – 3311)
1978 – 1993 "Fiziologicheskii zhurnal" (ISSN 0201 – 8489)
1994 – 2016 "Fiziolohichnyi zhurnal" (ISSN 0201 – 8489)
2017 – "Fiziolohichnyi zhurnal" (ISSN 2522-9028)

Fiziol. Zh. 2009; 55(5): 64-71

The action of l-arginine on prooxidantantioxidantstatus of rat vessels and lungs under experimental rhabdomyolisys

V.P. Fylymonenko, I.V. Nikitchenko, P.A. Kaliman

    Харків. нац. ун-т ім. В.Н. Каразіна М-ва освіти та науки України



Abstract

The glycerol administration was found to cause accumulation of the total heme in rat blood serum, vessels and lungs that are accompanied by increase of TBA-reactive products and pro­tein carbonyl derivates contents. A decrease of superoxide dismutase activity and an increase of reduced glutathione in lung were observed. Heme entering the vessels and lungs is accompanied by elevation in heme oxygenase activity. Pre-treatment by L-arginine (0.5 h before glycerol administration) didn’t affect blood serum and vessels changes caused by glyc-erol injection. However, in lungs, L-arginine prevents TBA-reactive products and protein carbonyl derivates accumula­tion, the decrease of superoxide dismutase activity and causes the ealier heme oxygenase induction. Prooxidant effects of heme in tissues studied and possible mechanisms of L-arginine protective action in lung under experimental rhabdomyolysis are discussed.

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