Nesteroffs method is a very simple and effective for diagnosis scin capillary resistance, this method is not only effective vor diagnosis, but it is very appliable for curing effectivness control. Women’s skim blood vessel conditions were investigend. Only the women of before climacteric period were invavend, all of them had microcirculation wich reduced elastans of scin. Reduction of capillary resistence is closly connectend with the degree of microcirculation distonia and connectend with it skin elastans reduction. We can tace into consideration that the changings found are connectend with the changings of blood vessel microcirculation. M icrocirculation distonia causes the changings of skin elastans