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ISSN 2522-9028 (Print)
ISSN 2522-9036 (Online)
DOI: https://doi.org/10.15407/fz

Fiziologichnyi Zhurnal

is a scientific journal issued by the

Bogomoletz Institute of Physiology
National Academy of Sciences of Ukraine

Editor-in-chief: V.F. Sagach

The journal was founded in 1955 as
1955 – 1977 "Fiziolohichnyi zhurnal" (ISSN 0015 – 3311)
1978 – 1993 "Fiziologicheskii zhurnal" (ISSN 0201 – 8489)
1994 – 2016 "Fiziolohichnyi zhurnal" (ISSN 0201 – 8489)
2017 – "Fiziolohichnyi zhurnal" (ISSN 2522-9028)

Fiziol. Zh. 2009; 55(5): 56-63

Intercellular reabsorption in the general systemabsorption of ethanol in gastrointestinal tract

N.Ya. Golovenko, I.Yu. Borisyuk, E.B. Lihota

    Фіз.-хім. ін-т ім. О.В. Богатського НАН України, Одеса



Abstract

Dynamic components of central nervous, cardio-vascular and respiratory systems in the conditions of present functional state of the body were evaluated on the basis of analysis of these system parameters registered simultaneously in the real­time regime. Power distributions of amplitude fluctuations of alpha-activity, cardio-intervals and respiratory periods were analyzed. It was shown that all the subjects in all the power distributions have periodical fluctuations in all three frequency ranges described for cardiac rhythm variability (CRV). The studied spectrums have different structure. In power distribu­tions of amplitude fluctuations of alpha-activity, slow and very slow waves are prevailing and fast waves constitute only 10%. In the spectrum of cardiac rhythm variability, fast and slow waves take half of all the power distributions, while another half is taken by very slow waves. In the spectrum of respiration rhythm, fast waves prevail (more than 60 %), along with this there are very slow waves (30%) and slow waves which take just 10%.

Keywords: 14C-ethanol, absorption, concentration gradient, reabsorption

Full text: (PDF, in Ukrainian)

References

  1. Богатский А.В., Головенке Н.Я., Зиньковский В.Г. Внутрипеченочная циркуляция 14С-феназепама и его метаболитов в организме белых крыс // Хим. -фарм. журн. - 1980. - №4. - С. 15-21.
  2. Головенко Н.Я. Физико-химическая фармакология. - Одесса: Астропринт, 2004. - 720 с.
  3. Головенко М., Борисюк І. Концепція «вікно всмоктування» в загальній фармацевтичній стратегії // Вісн. фармакології та фармації. - 2008. - №3. - С 43-49.
  4. Головенко М.Я., Борисюк І.Ю., Ларіонов В.Б., Ліхота О.Б. Особливості фармакокінетики етанолу в організмі білих мишей // Мед. хімія. - 2007. - №2. -С 60-63.
  5. Ларіонов В.Б. Співвідношення концентрацій етанолу у головному мозку та плазмі крові при його внутрішньовенному та інтрагастральному введенні мишам // Досягнення біології та медицини. - 2007. -10, №2. -С 42-46.
  6. Anderson M. Molecular structure of tight junction and their role in epithelial transport // News Physiol. Sci. -2001. - 16, №3. - P. 126-130.
  7. Arimori K., Nakano M. Drug exsorption from blood into the gastrointestinal tract // Pharm. Res. - 1998. -15, №3. - P. 371-376.
  8. Davenport H.W: Ethanol damage to canine oxyntic glandular mucosa // Proc. Soc. Exp. Biol. Med. - 1967. -126. - P. 657-662.
  9. 9. Gillespie R.J., Lucas C.C. Effect of single intoxicating doses of ethanol on the gastric and intestinal mucosa of rats // Can. J. Biochem. Physiol. - 1961. - 39. -P. 237-241.
  10. 10. Lennemas N., Regardh C. Dose-depend intestinal ab­sorption and significant intestinal excretion (exsorption) of the beta-blocker pafenolol in the rat // Ibid. - 1993. -10. - P. 727-731.
  11. Ma T., Nguyen D., Bui V. et al. Ethanol modulation of intestinal epithelial tight junction barrier // Amer. J. Physiol. - 1999. - 39, №4. - P. 965-974.
  12. Puurunen J., Karppanen H. Effects of ethanol on gas­tric acid secretion and gastric mucosal cyclic AMP the rat // Life Sci. - 1975. - 16. - P. 1513-1520.
  13. Rao R. Acetaldehyde - induced increase in paracellular permeability in Caco-2 cell monolayer // Alcohol. Clin. Exp. Res. - 1998. - 22, №8. - P. 1724-1730.
  14. Seitz H. , Posche G. The role of gastrointestinal factor in alcohol metabolism // Alcohol. Alcoholism. - 1997. -32, №5. - P. 543-549.
  15. Sheth P., Seth A., Trangavel M. et al. Epidermal grows factor prevents acetaldehyde-induced paracellular per­meability in Caco-2 cell monolayer // Ibid. - 2004. -28, №5. - P. 797-804.
  16. Suttle A., Brouwer K. Gastrointestinal transit and dis­tribution of ranitidine in the rat // Ibid. - 1995. - 12. -P. 1316-1322.
  17. Widdicombe J. Regulation of depth and composition of airway surface liquid // J. Anat. - 2002. - 201. -P. 313-318.
  18. Yu V.Y.H. Effect of body position on gastric emptying in the neonate // Arch. Dis Child. - 1975. - 50. -P. 500-504.
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