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ISSN 2522-9028 (Print)
ISSN 2522-9036 (Online)
DOI: https://doi.org/10.15407/fz

Fiziologichnyi Zhurnal

is a scientific journal issued by the

Bogomoletz Institute of Physiology
National Academy of Sciences of Ukraine

Editor-in-chief: V.F. Sagach

The journal was founded in 1955 as
1955 – 1977 "Fiziolohichnyi zhurnal" (ISSN 0015 – 3311)
1978 – 1993 "Fiziologicheskii zhurnal" (ISSN 0201 – 8489)
1994 – 2016 "Fiziolohichnyi zhurnal" (ISSN 0201 – 8489)
2017 – "Fiziolohichnyi zhurnal" (ISSN 2522-9028)

Fiziol. Zh. 2009; 55(5): 42-48


Morphological changes in the mucousmembrane of large intestine under the blockage of h+,k+-atpase and gastrin receptorscck-2

V.J. Kimakovich, P.O. Sklyarov, V.I. KovalyshyN.

    Львів.нац. мед. ун-т ім. Данила Галицького


Abstract

In experiments on rats, a 14-days blockade of H+,K+-ATPase with lansoprazole was revealed to cause structural disorders in the epitheliocytes and goblet cells, enhancement of prolif­eration processes in the mucous membrane of large intestine and increase of gastrin concentration in blood. The blockade of H+,K+-ATPase in epitheliocytes elicited an impairment of their structure, whereas activation of proliferative processes is caused by gastrin action. Morphological changes under the action of lansoprasole may cause disorders in the processes of ion transport, microhemodynamics and activation of prolif-erative processes. The blockade of CCK-2 gastrin receptors with proglumide resulted in a decrease of gastrin concentration in blood and reduction of lansoprazole action. Monitoring the blood gastrin levels is preferable to perform with the use of H+,K+-ATPase blockers and under condition of stomach hy-posecretion.

References

  1. Кімакович В.Й., Скляров П.О. Роль гастрину у процесах канцерогенезу товстої кишки //Практ. медицина. - 2007. - 13, № 1. - С 138-146.
  2. Ashust H.L., Varro A., Dimaline R. Regulation of mammalian gastrin/CCK receptor (CCK2R) expression in vitro and in vivo// Exp. Physiol. - 2007. - 93, № 2. -P.223-236.
  3. Danzer M., Jocic M., Samberger C. et al. Stomach-brain communication by vagal afferents in response to luminal acid backdiffusion, gastrin, and gastric acid secretion // Amer. J. Physiol. Gastrointest. Liver Physiol.- 2004. - 286, № 3. - G 403-411.
  4. Del Castillo J.R., Rajendran V.M., Binder H.J. Apical membrane localization of ouabain-sensitive K+-acti­vated ATPase activities in rat distal colon // Ibid. -1991. - 261, №6. - G 1005-1011.
  5. Dockray G.J., Varro A., Dimaline R., Wang T. The gastrins: their production and biological activities// Annu. Rev. Physiol. - 2001. - 63. - P.119-139.
  6. Glauert A.M. Fixation, dehydration and embedding of biological specimens. - In: Practical methods in elec­tron microscopy / North-Hollond (American Elsevier), 1975. - 207 p.
  7. Gonzales-Puga C.,Garcia-Navarro A. Selective CCK-A but not CCK-B receptor antagonists inhibit HT-29 cell proliferation:synergism with pharmacological lev­els of melatonin //J. Pineal. Res. - 2005. -39, № 3. -P. 243-250.
  8. Hirschowitz B.I., Simmons J., Mohnen J. Clinical out­come using lansoprazole in acid hypersecretors with and without Zollinger-Ellison syndrome: a 13-year prospective study// Clin. Gastroenterol. Hepatol. -2005. - 3,№1. - P. 39-48.
  9. 9. Hollande F., Imdahl A., Mantamadiotis T. et al. Glicine-extended gastrin acts as an autocrine growth factor in a nontransformed colon cell line//Gastroenterology. -1997. - 113. -P. 1576-1588.
  10. 10. Hurlenko T. M., Beregova T.V., Voronina O. I. et al. The effect of long-term hypergastrinemia on the colonic mucosa morphofunctional indexes and methods for prevention of induced changes. - In: III international conference “Neuro - humoral and cellular regulatory mechanisms of digestion processes” (October 4-6, 2007, Lviv, Ukraine). - Lviv, 2007. - P. 28-29.
  11. Mqssner J., Caca K. Developments in the inhibition of gastric acid secretion// Blackwell Synergy: Eur. J. Clin. Invest. - 2005. - 35, Issue 8. - P. 469-475.
  12. Piche T., Galmiche J.P. Pharmacological targets in gastro-oesophageal reflux disease// Basic Clin. Pharmacol. Toxicol. - 2005. - 97, № 6. - P.333-341.
  13. Seva C, Dickinson C.J., Yamada T. Growth-promot­ing effects of glycine-extended progastrin// Science. -1994. - 265. - P. 410-412.
  14. Shen K., He S., He Y. Effects of proglumide, a gastrin receptor antagonist, on human large intestine carcinoma SW480 cell line// Chin. Med. J. (Engl). - 1998. - 111, №12. - P. 1075-1078.
  15. Shin J.M., Vagin O., Munson K. et al. Molecular mecha­nisms in therapy of acid-related diseases// Cell Mol. Life Sci. - 2008. - 65, № 2. - P.264-281.
  16. Sklyarov P.A., Kimakovich V.J. Early changes of lipoperoxidation processes in the large intestine under blockage of H+,K+-ATPase, CCK-2 receptors andCOX-2 in rats. - In: 15th United European Gastroen­terology Week (27-31 October 2007), Gut. - 39. -Suppl 1. - P. A314.
  17. Smith A.M., Watson S.A. Review article: gastrin and colorectal cancer// Aliment. Pharmacol. Ther. - 2000. -14. - P.1231-1247.
  18. Takeuchi K., Speir G.R., Johnson L.R. Mucosal gas­trin receptor. III. Regulation by gastrin//Amer. J. Physiol. Gastrointest. Liver Physiol. - 1980. - 238. -G.1133-1140.
  19. 19. Takhar A.S., Eremin O., Watson S.A. The role of gas­trin in colorectal carcinogenesis// Surgeon. - 2004. - 2, № 5. - P. 251-257.
  20. 20. Thommesen L., Hofsli E., Paulssen R.H. Molecular mechanisms involved in gastrin - mediated regulation of cAMP - responsive promoter elements//Amer. J. Physiol. Enocrinol.Metab. - 2001. - 281. - E. 1316-1325.
  21. Triantafillidis J.K. , Merikas E., Govosdis V. et al. Increa­sed fasting serum levels of growth hormone and gastrin in patients with gastric and large bowel cancer// Hepato-gastroenterology. - 2003. - 50, Suppl 2. - cclvi-cclx.
  22. Watanabe T., Suzuki Y., Suzuki T. Ouabain-sensitive K(+)-ATPase in epithelial cells from guinea pig distal colon// Amer. J. Physiol. Gastrointest. Liver Physiol. -1990. - 258. - G. 506-511.
  23. Yao M., Song DH., Rana B., Wolfe MM. COX-2 se­lective inhibition reverses the trophic properties of gastrin in colorectal cancer// Brit. J. Cancer. - 2002. -87,№5. - P.574-579.
  24. Yassin R.R. Signaling pathways mediating gastrin’s growth-promoting effects// Peptides. - 1999. - 20. -P. 885-898.

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