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ISSN 2522-9028 (Print)
ISSN 2522-9036 (Online)
DOI: https://doi.org/10.15407/fz

Fiziologichnyi Zhurnal

is a scientific journal issued by the

Bogomoletz Institute of Physiology
National Academy of Sciences of Ukraine

Editor-in-chief: V.F. Sagach

The journal was founded in 1955 as
1955 – 1977 "Fiziolohichnyi zhurnal" (ISSN 0015 – 3311)
1978 – 1993 "Fiziologicheskii zhurnal" (ISSN 0201 – 8489)
1994 – 2016 "Fiziolohichnyi zhurnal" (ISSN 0201 – 8489)
2017 – "Fiziolohichnyi zhurnal" (ISSN 2522-9028)

Fiziol. Zh. 2009; 55(5): 28-34

Effect of ucp2 activity inhibitor genipin onheart function of aging rats

Y.V. Goshovska, T.V. Shimanskaya, V.F. SagacH.

    Ін-т фізіології ім. О.О. Богомольця НАН України, Київ



Abstract

To estimate the role of uncoupling proteins in aging rat heart recovery from prolonged ischemia we used genipin applica­tion during Langendorf preparation. It was shown that genipin in dose-depended manner depressed coronary flow, heart rate and cardiac diastolic function. Such effect was similar to that observed during myocardial Ca2+ overload by gradually el­evated CaCl2 in perfusion solution. Moreover, postischemicdisturbances of cardiodynamic parameters, oxygen cost of myocardial work were much increased in genipin pretreated hearts that in control ones. Thus, genipin inhibition of UCP2 activity has cardiodepressive effects that imply UCPs in cardiac calcium regulation.

Full text: (PDF, in Ukrainian)

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