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ISSN 2522-9028 (Print)
ISSN 2522-9036 (Online)
DOI: https://doi.org/10.15407/fz

Fiziologichnyi Zhurnal

is a scientific journal issued by the

Bogomoletz Institute of Physiology
National Academy of Sciences of Ukraine

Editor-in-chief: V.F. Sagach

The journal was founded in 1955 as
1955 – 1977 "Fiziolohichnyi zhurnal" (ISSN 0015 – 3311)
1978 – 1993 "Fiziologicheskii zhurnal" (ISSN 0201 – 8489)
1994 – 2016 "Fiziolohichnyi zhurnal" (ISSN 0201 – 8489)
2017 – "Fiziolohichnyi zhurnal" (ISSN 2522-9028)

Fiziol. Zh. 2009; 55(4): 50-57

Antiatherogenic propertyof “korvitin”: effect on proteasome activity in aorta, heart and blood cells

D.O.pashevin, V.E.dosenko, YU.V.byts, A.A.moibenko

    Ін-т фізіології ім. О.О. Богомольця НАН України, Київ;Нац. мед. ун-т ім. О.О. Богомольця, Київ



Abstract

We studied the changes in proteasomal proteolisis during model­ling of rabbit cholesterol-induced atherosclerosis. It was deter­mined that in aorta the TL activity of proteasome increased 2,4-fold (P<0,05), CTL activity increased by 43 %, and PGPG – by 10 %. In heart tissue it was observed the increase of CTL proteasome activity by 14 %. The application of “Korvitin” (water-soluble form of quercetine) followed by considerable decrease of proteasomal activity both in tissues (aorta and heart) and leucocytes. The intensity of atherosclerotic changes in aorta was significantly smaller. Obtained data suggest that “Korvitin” reveales angioprotective properties mediated by it effect on proteasomal proteolisis.

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