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ISSN 2522-9028 (Print)
ISSN 2522-9036 (Online)
DOI: https://doi.org/10.15407/fz

Fiziologichnyi Zhurnal

is a scientific journal issued by the

Bogomoletz Institute of Physiology
National Academy of Sciences of Ukraine

Editor-in-chief: V.F. Sagach

The journal was founded in 1955 as
1955 – 1977 "Fiziolohichnyi zhurnal" (ISSN 0015 – 3311)
1978 – 1993 "Fiziologicheskii zhurnal" (ISSN 0201 – 8489)
1994 – 2016 "Fiziolohichnyi zhurnal" (ISSN 0201 – 8489)
2017 – "Fiziolohichnyi zhurnal" (ISSN 2522-9028)

Fiziol. Zh. 2009; 55(4): 32-40


Oxidative stress in cardiovascularsystem at chronic deficiency of cerebral dopamine in rats

S.A. Talanov, A.V. Kotsuruba, YU.P. Korkach, V.F. Sahach

    O.O.Bogomoletz Institute of Physiology, National Academyof Sciences of Ukraine, Kyiv



The physiological significance of cardiac mitochondrial reactive oxygen species (ROS) regulation is unknown. In the current study, mitochondrial ROS (.O2- and .OH) generation, stable H2O2 and lipids peroxidation marker (malonic dialdehyde, MDA) pools, as well as pools of potent antioxidants – urea and uric acid – were determined in rat heart, miocardial mito­chondria and in blood plasma and erytrocytes at low (44 %) and high (96 %) levels of cerebral dopamine-synthesis neurons destruction (by 6-hydroxidopamine treatment). In the untreated rats, ROS generation, H2O2 and MDA levels were low but in rats with chronic (3-4 month) deficiency of cerebral dopamine synthesis by nigro-striatal dopaminergic system, ROS genera­tion and lipids peroxidation were progressively increased. Dopamine deficiency can improve mitochondrial efficiency of oxidative phosphorylation due to oxidative stress.

© National Academy of Sciences of Ukraine, Bogomoletz Institute of Physiology, 2014-2025.