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ISSN 2522-9028 (Print)
ISSN 2522-9036 (Online)
DOI: https://doi.org/10.15407/fz

Fiziologichnyi Zhurnal

is a scientific journal issued by the

Bogomoletz Institute of Physiology
National Academy of Sciences of Ukraine

Editor-in-chief: V.F. Sagach

The journal was founded in 1955 as
1955 – 1977 "Fiziolohichnyi zhurnal" (ISSN 0015 – 3311)
1978 – 1993 "Fiziologicheskii zhurnal" (ISSN 0201 – 8489)
1994 – 2016 "Fiziolohichnyi zhurnal" (ISSN 0201 – 8489)
2017 – "Fiziolohichnyi zhurnal" (ISSN 2522-9028)

Fiziol. Zh. 2009; 55(3): 133-140

PECULIARITIES OF URIC ACID BALANCE DISORDERS IN PATIENTS WITH TYPE 2 DIABETES AND METABOLIC SYNDROME

V.V. Korpachev, N.M. Gurina, T.I. Korpacheva, A.A. Shuprovich, I.A. Mosendz

    V.P. Komissarenko Institute of Endocrinology and Metabolism of AMS, Kyiv, Ukraine



Abstract

Hyperuricemia (HU) is considered to be a sign of metabolic syndrome as a consequence of purine metabolism disorder. To investigate alterations in uric acid (UA) methabolism, 90 sub­jects (M/F 53/37, aged 58±4 yr) with type 2 diabetes mellitus (DM2) were divided into 5 groups depending on the amount of excreted UA and its content in blood plasma. HU was found in 29% of patients, while hyperpoduction of UA was characteristic in 87% patients. Normo- or hypouricemia in majority of patients were mostly connected to kidney hyperfiltration and “compensatory” hyperuricosuria. HU with decreased UA ex­cretion (“kidney” HU) was characteristic of severe DM2 with reduced kidney filtration rate. “Metabolic” HU with increased formation and excretion rated of UA was observed only in obese men.. Increased insulinemia levels and insulin resistance index (IR) were found in obese patients in comparison with subjects with normal weight, independently of the type of UA excretion disorder. IR strongly correlated with serum UA levels in all groups of patients. The results suggest the significance of insulin resistance and abdominal obesity in UA metabolism in DM2.

Keywords: Hyperuricemia, purine metabolism disorder, uric acid, type 2 diabetes mellitus

Full text: (PDF, in Ukrainian)

References

  1. Balkarov IM Gout (urate) kidney. In the book: Diagnosis and therapy in the clinic of internal medicine. M. : Human Health, 2004. p. 219-233.
  2. Barskova VG, Nasonova VA, Yakunina IA et al. On the severity of female gout . Therapist. archive. 2005. 77, N 5. P. 58-62.
  3. Gurina NM, Korpachev VV, Shuprovich AA Disorders of uric acid metabolism depending on the degree of insulin resistance and obesity in patients with type 2 diabetes mellitus: Proceedings of the Congress of Endocrinologists of Ukraine, 2007 . Endocrinology. 2007. 12, dod. p.61.
  4. Madyanov IV, Balabolkin MI, Grigoriev AA Hyperuricemia as a component of the metabolic syndrome . Probl. endocrinology. 1997. 43, N 6. P.30-33.
  5. Madyanov IV, Balabolkin MI, Markov DS, Markova TN. The main causes of hyperuricemia in diabetes mellitus . Therapist. archive. 2000. N 2. p.58-60.
  6. Mukhin NA, Balkarov PM, Britov AN Tubulointerstitial nephritis and arterial hypertension clinical and population significance . Ibid. 1997. 69, N 7. p.5-10.
  7. Mukhin NA, Balkarov IM, Moiseev SV. et al. Chronic progressive nephropathy and lifestyle of modern man . Ibid. 2004. 76, N 9. p. 5-10.
  8. Tronko MD, Korpacheva-Zinich OV Gender and sexual features of diabetes K .: Book Plus, 2008. 208 p.
  9. Berne C., Jensevic K., Berglund L. et al. The meta­bolic syndrome as predictor of coronary heart disease, all-cause mortality and insulin resistance the influence of choice of criteria . Diabetologia. 2006. 49, p. 1. P.230.
  10. Bonora E., Bonadonna R. Hyperinsulinemia and insulin resistance are independently associated with plasma lipids, uric acid and blood pressure in nondiabetic subjects . Ibid. 2002. 45, S.l. N1 (38th EASD Congr.). P.A184.
  11. Haffner S.M. Sex hormones, obesity, fat distribution, type 2 diabetes and insulin resistance: epidemiological and clinical correlation . Int. J. Obes. Relat. Metab. Disord. 2000. 24, N 2. P. 56-58.
  12. Reaven G. The kidney: An anwilling accomplice in syn­drome X . Amer. J. Kidney Dis. 1997. 30, N 6. P. 928-931.
  13. Sallstorm J., Carlsson P., Fredholm B. Dibetes-induced hyperfiltration in adenosine A1-receptor deficient mice lacking the tubulo-glomerular feedback mechanism . Diabetologia. 2006. 49, S1. P.652.
  14. Shichiri M., Iwamoto H., Marumo F. Diabetic hypouri-cemia as an indicator of clinical nephropathy . Amer. J. Nephrol. 1990. 10, N 2. P.115-122.
  15. Sinagra D., Green D., Scarpitta A.M., Bonaventura V. Serum uric acid, insulin secretion and resistance in nonhyperuricemic and hyperuricemic obese female sub­jects . Int. J.Obes. 1996. 20, N 11. P.1041-1043.
  16. Taniguchi Y., Hayashi T., Tsumura K. et al. Serum uric acid and risk for hypertension and type 2 diabetes in Japanese men: The Osaca Helth Survey . J. Hypertens. 2001. 9,N 7. P.1209-1215.
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