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ISSN 2522-9028 (Print)
ISSN 2522-9036 (Online)
DOI: https://doi.org/10.15407/fz

Fiziologichnyi Zhurnal

is a scientific journal issued by the

Bogomoletz Institute of Physiology
National Academy of Sciences of Ukraine

Editor-in-chief: V.F. Sagach

The journal was founded in 1955 as
1955 – 1977 "Fiziolohichnyi zhurnal" (ISSN 0015 – 3311)
1978 – 1993 "Fiziologicheskii zhurnal" (ISSN 0201 – 8489)
1994 – 2016 "Fiziolohichnyi zhurnal" (ISSN 0201 – 8489)
2017 – "Fiziolohichnyi zhurnal" (ISSN 2522-9028)

Fiziol. Zh. 2009; 55(3): 94-99


NITRIC OXIDE SYNTHESIS IN GIRLS DURING LONG-TERM ADAPTATION TO INTENSIVE MUSCULAR WORK

N.V. Bogdanovskaya1, A.N. Svyatodouh1., A.V. Kotsuruba2, Yu.P. Korkach2, N.V. Malikov1

  1. Zaporozhye state university, Zaporozhye, Ukraine
  2. O.O. Bogomoletz Institute of Physiology National Academyof Sciences of Ukraine, Kyiv, Ukraine


Abstract

14 trained and 21 non-trained girls 18-22 years of age have been inspected. We found that systematically trained girls had a higher level of nitric oxide synthesis through calcium-dependent L-arginine oxidation by constitutive NO-synthase isoforms (eNOS, nNOS) and through reduction of stable oxidized NO metabolites. NO synthesized de novo in calcium-dependent path­way provides a long-term organism adaptation to physical loads of high volume and intensity at the beginning and in the middle of stress-aggravated competition period. At the end of competition period we detected significant activation of induc-ible calcium-independent de novo NO synthesis from L-arginine.

Keywords: nitric oxide synthesis, long-term adaptation, intensive muscular work

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