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Fiziologichnyi Zhurnal - <a id="lj1_ret_bk_to_jl0_href_id" href="?list0=11">Fiziol. Zh. 2009;</a> <a id="lj1_ret_bk_to_jl0_href_id" href="?list1=54">55(3):</a> 94-99
Українська Русский English

ISSN 2522-9028 (Print)
ISSN 2522-9036 (Online)
DOI: https://doi.org/10.15407/fz

Fiziologichnyi Zhurnal

is a scientific journal issued by the

Bogomoletz Institute of Physiology
National Academy of Sciences of Ukraine

Editor-in-chief: V.F. Sagach

The journal was founded in 1955 as
1955 – 1977 "Fiziolohichnyi zhurnal" (ISSN 0015 – 3311)
1978 – 1993 "Fiziologicheskii zhurnal" (ISSN 0201 – 8489)
1994 – 2016 "Fiziolohichnyi zhurnal" (ISSN 0201 – 8489)
2017 – "Fiziolohichnyi zhurnal" (ISSN 2522-9028)

Fiziol. Zh. 2009; 55(3): 94-99

Nitric oxide synthesis in girls during long-term adaptation to intensive muscular work

N.V. bogdanovskaya, A.N. svyatodouh A., A.V. kotsuruba, YU.P. korkach, N.V. malikoV.

    Zaporozhye state university, Zaporozhye, Ukraine;O.O. Bogomoletz Institute of Physiology National Academyof Sciences of Ukraine, Kyiv


14 trained and 21 non-trained girls 18-22 years of age have been inspected. We found that systematically trained girls had a higher level of nitric oxide synthesis through calcium-dependent L-arginine oxidation by constitutive NO-synthase isoforms (eNOS, nNOS) and through reduction of stable oxidized NO metabolites. NO synthesized de novo in calcium-dependent path­way provides a long-term organism adaptation to physical loads of high volume and intensity at the beginning and in the middle of stress-aggravated competition period. At the end of competition period we detected significant activation of induc-ible calcium-independent de novo NO synthesis from L-arginine.


  1. Аронов Д.М. Кардиологическая реабилитация на рубеже веков // Сердце. -2002. - №3. - С.123-125.
  2. Марков Х.М. Оксид азота и сердечно-сосудистая система // Успехи физиол. наук. - 2001. - 32, № 3. -С. 49-65.
  3. Мойбенко А.А., Павлюченко В.Б., Даценко В.В., Майский В.А. Роль оксида азота в механизмах формирования рефлекторных вазомоторных реакций //Там же. - 2005. -№4. - C. 3-14.
  4. Петрищев Н.Н., Власов Т.Д. Физиология и патофи­зиология эндотелия. Дисфункция эндотелия. Причи-ны, механизмы, фармакологическая коррекция. -СПб: Изд-во СПбГМУ, 2003. - 38 с.
  5. Сагач В.Ф. Роль оксида азота в регуляции крово­обращения. - В кн.: Пурины и монооксид азота. Регуляторная функция в организме. - Минск: Технопринт, 2003. - C. 110-113.
  6. Clarcson P., Montgomery H.E., Mullen M.J. et al. Exer­cise training enhances endothelial function in young men // J. Amer. Coll. Cardiol. - 1999. - 33. - P.1379-1385.
  7. Hambrecht R., Wolf A., Gielen S. et al. Effect of physical exercise on coronary endothelial function in coronary artery disease // N.Engl. J. Med. - 2000. - 342. - P.454-460.
  8. Lavrentic A., Salobir B.G., Keber I. Physical training improves flow-mediated dilatation in patients with the polymetobolic syndrome // Arterioscler. Thromb. Vas­cular. Biol. - 2000. - 20. - P.551-555.
  9. 9. Linke A., Schoene N., Gielen S. et al. Endothelial dys­function in patients with chronic heart failure: systemic effects of lower-limb exercise training // J. Amer. Coll. Cardiol. - 2001. - 37. - P.392-397.
  10. 10. McAllister R.M. Endothelial-mediated control of coronary and skeletal muscle blood flow during exer­cise: introduction // Med. Sci. Sports. Exerc. - 1995. -27, №8. - P.1 122-124.
  11. Niebauer J., Cooke J.P. Cardiovascular effects of ex­ercise: role of endothelial shear stress// J. Amer. Coll. Cardiol. - 1996. - 28, №7. - P.1652-1660.

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