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ISSN 2522-9028 (Print)
ISSN 2522-9036 (Online)

Fiziologichnyi Zhurnal

is a scientific journal issued by the

Bogomoletz Institute of Physiology
National Academy of Sciences of Ukraine

Editor-in-chief: V.F. Sagach

The journal was founded in 1955 as
1955 – 1977 "Fiziolohichnyi zhurnal" (ISSN 0015 – 3311)
1978 – 1993 "Fiziologicheskii zhurnal" (ISSN 0201 – 8489)
1994 – 2016 "Fiziolohichnyi zhurnal" (ISSN 0201 – 8489)
2017 – "Fiziolohichnyi zhurnal" (ISSN 2522-9028)

Fiziol. Zh. 2009; 55(3): 94-99


N.V. Bogdanovskaya1, A.N. Svyatodouh1., A.V. Kotsuruba2, Yu.P. Korkach2, N.V. Malikov1

  1. Zaporozhye state university, Zaporozhye, Ukraine
  2. O.O. Bogomoletz Institute of Physiology National Academyof Sciences of Ukraine, Kyiv, Ukraine


14 trained and 21 non-trained girls 18-22 years of age have been inspected. We found that systematically trained girls had a higher level of nitric oxide synthesis through calcium-dependent L-arginine oxidation by constitutive NO-synthase isoforms (eNOS, nNOS) and through reduction of stable oxidized NO metabolites. NO synthesized de novo in calcium-dependent path­way provides a long-term organism adaptation to physical loads of high volume and intensity at the beginning and in the middle of stress-aggravated competition period. At the end of competition period we detected significant activation of induc-ible calcium-independent de novo NO synthesis from L-arginine.

Keywords: nitric oxide synthesis, long-term adaptation, intensive muscular work


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