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ISSN 2522-9028 (Print)
ISSN 2522-9036 (Online)
DOI: https://doi.org/10.15407/fz

Fiziologichnyi Zhurnal

is a scientific journal issued by the

Bogomoletz Institute of Physiology
National Academy of Sciences of Ukraine

Editor-in-chief: V.F. Sagach

The journal was founded in 1955 as
1955 – 1977 "Fiziolohichnyi zhurnal" (ISSN 0015 – 3311)
1978 – 1993 "Fiziologicheskii zhurnal" (ISSN 0201 – 8489)
1994 – 2016 "Fiziolohichnyi zhurnal" (ISSN 0201 – 8489)
2017 – "Fiziolohichnyi zhurnal" (ISSN 2522-9028)

Fiziol. Zh. 2000; 46(6): 90-98


Mechanisms of enhanced vascular contractilityin experimental animals and human under conditionof atherosclerosis

A. V. Gurkovskaya, A. I. Pliska, V. A. Buryi, N. I. Gokina

    A.A.Bogomoletz Institut of PhysiologyNаtional Academy of Scence of Ukraine, Kiev


Abstract

Contractile and electrical responses of muscle strips from rabbit aorta to 5-HT and hyper K solution were compared in controls group of rabbits fed a normal diet, and atherosclerotic animals fed 1% cholesterol diet for 12 weeks (atherosclerotic group). A study of vascular responses of human popliteal artery was also carried out.It was shown that smooth muscle cells from arteriosclerotic vessels of both rabbits and human exhibit an increased sensitivity to contractile action of hyperpotassium solution and 5-HT. We found no significant difference in the densities of L-type Ca2+ channel current as well as voltage dependent K+ channels current measured by patch clamp method in single smooth muscle cells from control and atherosclerotic rabbit aorta. Removal of endotelium from the vascular strips resulted in an enhanced vascular contractility in control but not in atherosclerotic group. The dose response curves for endothelium-free muscle strips for both 5-HT and hyper K solution were not significantly different between the two groups. Our result suggest that the enhanced vascular responses to 5-HT and hyper K under condition of arteriosclerosis could be attributed to an impaired function of endothelium which is a source of substances particularly nitric oxide that mediates vascular relaxation and provides a compensatory mechanism to keep periferal resistance at lower level.

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