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ISSN 2522-9028 (Print)
ISSN 2522-9036 (Online)
DOI: https://doi.org/10.15407/fz

Fiziologichnyi Zhurnal

is a scientific journal issued by the

Bogomoletz Institute of Physiology
National Academy of Sciences of Ukraine

Editor-in-chief: V.F. Sagach

The journal was founded in 1955 as
1955 – 1977 "Fiziolohichnyi zhurnal" (ISSN 0015 – 3311)
1978 – 1993 "Fiziologicheskii zhurnal" (ISSN 0201 – 8489)
1994 – 2016 "Fiziolohichnyi zhurnal" (ISSN 0201 – 8489)
2017 – "Fiziolohichnyi zhurnal" (ISSN 2522-9028)

Fiziol. Zh. 2009; 55(2): 37-43


Omega-3 polyunsaturated fatty acids elevate the expression of ppar target genes

S.P. Kaplinskiy, A.M. Shysh, V.S. Nagibin, V.E. Dosenko, A.A. MoibenkO.

    O.O. Bogomoletz Institute of Physiology, National AcademySciences of Ukraine, Kyiv;Shemyakin-Ovchinnikov Institute of BioorganicChemistry, Russian Academy of Sciences, Russia;International Center of Molecular Physiology NationalAcademy Sciences of Ukraine, Kyiv


Abstract

In experiments on isolated neonatal cardiomyocytes and hearts of adult rats we investigated the influence of polyunsaturated fatty acids (PUFA) on expression of two peroxisome proliferator-activated receptor (PPAR) target genes - fatty acid transport protein (FATP) and interleukin-1 receptor antagonist (IL-1ra). We determined that cell membranes of adult rats heart and car-diomyocytes of neonatal rats which were born by females fed with w-3 PUFA for 4 weeks, contain more w-3 PUFA (alpha-linolenic and docosahexaenoic acids) in comparison with the control. It was shown that w-3 PUFA elevated FATP and IL-1ra mRNA expression in 2,25 (P=0,07) and 8,4 (P<0.00001) folds correspondingly in adult rats tissues. In isolated cardiomyo-cytes, the mRNA expression of FATP and IL-1ra were aug-mented 2.5 folds (P=0,22) and 8,1 folds (P<0.00001), accordingly. Our data show that w-3 PUFA stimulate PPAR target genes expression and allow to permit genetic mechanisms in cardio­protective effects of w-3 PUFA.

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