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ISSN 2522-9028 (Print)
ISSN 2522-9036 (Online)
DOI: https://doi.org/10.15407/fz

Fiziologichnyi Zhurnal

is a scientific journal issued by the

Bogomoletz Institute of Physiology
National Academy of Sciences of Ukraine

Editor-in-chief: V.F. Sagach

The journal was founded in 1955 as
1955 – 1977 "Fiziolohichnyi zhurnal" (ISSN 0015 – 3311)
1978 – 1993 "Fiziologicheskii zhurnal" (ISSN 0201 – 8489)
1994 – 2016 "Fiziolohichnyi zhurnal" (ISSN 0201 – 8489)
2017 – "Fiziolohichnyi zhurnal" (ISSN 2522-9028)

Fiziol. Zh. 2009; 55(2): 30-36


RADIATION DOES NOT AFFECT CALCIUM-DEPENDENT PATHWAY OF NITROGLYCERINE-EVOKED RELAXATION OF RAT AORTA

S.M. Zelenskyi, A.I. Solovyov

    Institute of Pharmacology and Toxycology AcademyMedical Sciences of Ukraine, Kyiv, Ukraine


Abstract

The effects of nitroglycerine (NG, 10-7 -10-4 M) on contractile force and intracellular calcium concentration ([Ca2+]i) in deendotelized thoracic aorta smooth muscles (SM) precontracted with high K+ in control and g-irradiated rats (6Gy) were investigated. NG-induced activation of soluble guanylate cyclase (sGC) as dominating pathway of NG- induced SM relaxation without related decrease in [Ca2+]i level is demonstrated. Radiation was without effect on this sGC-dependent and [Ca2+]i - independent NG-induced relaxation of vascular smooth muscle but decreased the basal levels of [Ca2+]i by (28,4±11,9 )% (6Gy, 9th-day).

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