Radiation does not affect calcium-dependent pathway ofnitroglycerine-evoked relaxation of rat aorta.
S.M. Zelenskyi,A.I. SolovyoV.
Institute of Pharmacology and Toxycology AcademyMedical Sciences of Ukraine, Kyiv
Abstract
The effects of nitroglycerine (NG, 10-7 -10-4 M) on contractile force and intracellular calcium concentration ([Ca2+]i) in deendotelized thoracic aorta smooth muscles (SM) precontracted with high K+ in control and g-irradiated rats (6Gy) were investigated. NG-induced activation of soluble guanylate cyclase (sGC) as dominating pathway of NG- induced SM relaxation without related decrease in [Ca2+]i level is demonstrated. Radiation was without effect on this sGC-dependent and [Ca2+]i - independent NG-induced relaxation of vascular smooth muscle but decreased the basal levels of [Ca2+]i by (28,4±11,9 )% (6Gy, 9th-day).
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