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ISSN 2522-9028 (Print)
ISSN 2522-9036 (Online)
DOI: https://doi.org/10.15407/fz

Fiziologichnyi Zhurnal

is a scientific journal issued by the

Bogomoletz Institute of Physiology
National Academy of Sciences of Ukraine

Editor-in-chief: V.F. Sagach

The journal was founded in 1955 as
1955 – 1977 "Fiziolohichnyi zhurnal" (ISSN 0015 – 3311)
1978 – 1993 "Fiziologicheskii zhurnal" (ISSN 0201 – 8489)
1994 – 2016 "Fiziolohichnyi zhurnal" (ISSN 0201 – 8489)
2017 – "Fiziolohichnyi zhurnal" (ISSN 2522-9028)

Fiziol. Zh. 2009; 55(2): 24-29

THE EFFECT OF DOSED NORMOBARIC HYPOXIA ON PHYSIOLOGIC REGENERATION OF LIVER PARENCHIMA IN YOUNG AND OLD RATS

V.A. Berezovskiy, R.V. Yanko, I.G. Litovka

    О.О. Bogomoletz Institute of Physiology, National Academyof Sciences of Ukraine, Kyiv, Ukraine



We studied the effect of dosed normobaric hypoxia during 28 days on functional state and physiological regeneration of liverparenchyma. After completion of experiments in 3 and 9-month old rats we observed an increase in the amount of hepa-tocytes per unit of tissue area, with hypertrophied nucleus and decreased cytoplasmic area. IGF-I gene expression in 9-month old animals was increased. Thus, our study suggests that normobaric hypoxia stimulates physiological regeneration of liver parenchyma in young and adult rats.

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