PEPTIDE COMPONENTS OF LYCOSA SPIDER VENOM MODULATE P2X RECEPTROR ACTIVITY OF RAT DRG NEURONS
G.A.Savchenko1, A.A.Vassilevski2, K.A.Pluzhnikov2, Y.V.Korolkova2, M.V.Mamenko1, T.M.Volkova1, O.P.Maximyuk1,3, Ya.A.Boychuk1, E.V.Grishin2, O.O.Krishtal1,3
- O.O. Bogomoletz Institute of Physiology, National Academy Sciences of Ukraine, Kyiv, Ukraine
- Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, Russia
- International Center of Molecular Physiology National Academy Sciences of Ukraine, Kyiv, Ukraine
Abstract
Almost each natural venom comprises a considerable combinatorial library of bioactive substances that have been optimized during evolution. Particular attention is devotedcurrently on a search for new modulators of ion channels from the venoms of arthropods. We have studied the effect of peptidous compounds of the Lycosa spider venom on the activity of P2X receptors in DRG neurons of rats. As a result, at least 7 proteins modulating various P2X receptor-operated ionic currents in the sensory neurons of rats have been found.
Keywords:
bioactive substances, P2X receptors, DRG neurons
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