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ISSN 2522-9028 (Print)
ISSN 2522-9036 (Online)

Fiziologichnyi Zhurnal

is a scientific journal issued by the

Bogomoletz Institute of Physiology
National Academy of Sciences of Ukraine

Editor-in-chief: V.F. Sagach

The journal was founded in 1955 as
1955 – 1977 "Fiziolohichnyi zhurnal" (ISSN 0015 – 3311)
1978 – 1993 "Fiziologicheskii zhurnal" (ISSN 0201 – 8489)
1994 – 2016 "Fiziolohichnyi zhurnal" (ISSN 0201 – 8489)
2017 – "Fiziolohichnyi zhurnal" (ISSN 2522-9028)

Fiziol. Zh. 2009; 55(2): 11-16


G.A.Savchenko1, A.A.Vassilevski2, K.A.Pluzhnikov2, Y.V.Korolkova2, M.V.Mamenko1, T.M.Volkova1, O.P.Maximyuk1,3, Ya.A.Boychuk1, E.V.Grishin2, O.O.Krishtal1,3

  1. O.O. Bogomoletz Institute of Physiology, National Academy Sciences of Ukraine, Kyiv, Ukraine
  2. Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, Russia
  3. International Center of Molecular Physiology National Academy Sciences of Ukraine, Kyiv, Ukraine


Almost each natural venom comprises a considerable combinatorial library of bioactive substances that have been optimized during evolution. Particular attention is devotedcurrently on a search for new modulators of ion channels from the venoms of arthropods. We have studied the effect of peptidous compounds of the Lycosa spider venom on the activ­ity of P2X receptors in DRG neurons of rats. As a result, at least 7 proteins modulating various P2X receptor-operated ionic currents in the sensory neurons of rats have been found.

Keywords: bioactive substances, P2X receptors, DRG neurons


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