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ISSN 2522-9028 (Print)
ISSN 2522-9036 (Online)
DOI: https://doi.org/10.15407/fz

Fiziologichnyi Zhurnal

is a scientific journal issued by the

Bogomoletz Institute of Physiology
National Academy of Sciences of Ukraine

Editor-in-chief: V.F. Sagach

The journal was founded in 1955 as
1955 – 1977 "Fiziolohichnyi zhurnal" (ISSN 0015 – 3311)
1978 – 1993 "Fiziologicheskii zhurnal" (ISSN 0201 – 8489)
1994 – 2016 "Fiziolohichnyi zhurnal" (ISSN 0201 – 8489)
2017 – "Fiziolohichnyi zhurnal" (ISSN 2522-9028)

Fiziol. Zh. 2009; 55(2): 11-16


Peptidecomponents of lycosa spider venom modulate p2x receptror activity of rat drg neurons

G.A. Savchenko, A.A. Vassilevski, K.A. Pluzhnikov, Y.V. Korolkova, M.V. Mamenko,T.M. Volkova, O.P. Maximyuk, YA.A. Boychuk, E.V. Grishin, O.O. KrishtaL.

    O.O. Bogomoletz Institute of Physiology, National AcademySciences of Ukraine, Kyiv;Shemyakin-Ovchinnikov Institute of BioorganicChemistry, Russian Academy of Sciences, Russia;International Center of Molecular Physiology NationalAcademy Sciences of Ukraine, Kyiv


Abstract

Almost each natural venom comprises a considerable combinatorial library of bioactive substances that have been optimized during evolution. Particular attention is devotedcurrently on a search for new modulators of ion channels from the venoms of arthropods. We have studied the effect of peptidous compounds of the Lycosa spider venom on the activ­ity of P2X receptors in DRG neurons of rats. As a result, at least 7 proteins modulating various P2X receptor-operated ionic currents in the sensory neurons of rats have been found.

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