POLYMORPHISM OF PROTEASOME GENES IS ASSOCIATED WITH AN ENHANCED RISK FOR ARTERIAL HYPERTENSION IN ADOLESCENTS
S.V. Goncharov1, V.E. Dosenko1, N.V. Haitovich2, A.A.Moibenko1
- O.O. Bogomoletz Institute of Physiology, National Academy Sciences of Ukraine, Kyiv, Ukraine
- O.O. Bogomoletz National Medical University, Kyiv, Ukraine
Abstract
Large multifunctional protease LMP2 (Arg60 -> His), LMP7 (Lys145 -> Gln) and PSMA6 (C–8 -> G) gene allelic polymorphisms in 147 young patients with essential hypertension andin 208 practically healthy people were determinated. It was shown that interrelation of genotypes Arg/Arg, Arg/His and His/His in LMP2 gene polymorphisms account 42,5 %, 46,4% and 11,1% correspondingly (in control - 63,9%, 28,6%, 7,5%; P=0.001 by c2-test). Allelic variants of PSMA6 dispense the next manner: C/C - 76,2%, C/G - 21,1%, G/G - 2,7% in adoles-cents with EH (in control - 69,8%, 29,7% and 0,5% correspondingly, P=0,047). Analysis of LMP7 gene polymorphism showed identical frequency of different genotypes in patients (Lys/Lys - 92,4%, Lys/Gln - 7,6%, Gln/Gln - 0%) and practically healthy people (97,3%, 2,7%, 0% correspondingly; P=0.16). Obtained data suggest the LMP2 and PSMA6 gene polymorphisms significance as the risk factors of essential hypertension in adolescents.
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