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ISSN 2522-9028 (Print)
ISSN 2522-9036 (Online)
DOI: https://doi.org/10.15407/fz

Fiziologichnyi Zhurnal

is a scientific journal issued by the

Bogomoletz Institute of Physiology
National Academy of Sciences of Ukraine

Editor-in-chief: V.F. Sagach

The journal was founded in 1955 as
1955 – 1977 "Fiziolohichnyi zhurnal" (ISSN 0015 – 3311)
1978 – 1993 "Fiziologicheskii zhurnal" (ISSN 0201 – 8489)
1994 – 2016 "Fiziolohichnyi zhurnal" (ISSN 0201 – 8489)
2017 – "Fiziolohichnyi zhurnal" (ISSN 2522-9028)

Fiziol. Zh. 2009; 55(2): 3-10


Polymorphismof proteasome genes is associated with an enhanced risk for arterial hypertensionin adolescents

S.V. Goncharov, V.E. Dosenko, N.V. Haitovich, A.A.moibenkO.

    S.V. Goncharov, V.E. Dosenko, N.V. Haitovich, A.A.Moibenko.


Abstract

Large multifunctional protease LMP2 (Arg60 -> His), LMP7 (Lys145 -> Gln) and PSMA6 (C–8 -> G) gene allelic polymor­phisms in 147 young patients with essential hypertension andin 208 practically healthy people were determinated. It was shown that interrelation of genotypes Arg/Arg, Arg/His and His/His in LMP2 gene polymorphisms account 42,5 %, 46,4% and 11,1% correspondingly (in control - 63,9%, 28,6%, 7,5%; P=0.001 by c2-test). Allelic variants of PSMA6 dispense the next manner: C/C - 76,2%, C/G - 21,1%, G/G - 2,7% in adoles-cents with EH (in control - 69,8%, 29,7% and 0,5% correspondingly, P=0,047). Analysis of LMP7 gene poly­morphism showed identical frequency of different genotypes in patients (Lys/Lys - 92,4%, Lys/Gln - 7,6%, Gln/Gln - 0%) and practically healthy people (97,3%, 2,7%, 0% correspon­dingly; P=0.16). Obtained data suggest the LMP2 and PSMA6 gene polymorphisms significance as the risk factors of essen­tial hypertension in adolescents.

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