THE INFLUENCE OF INTRODUCTION OF PROTEINASE INHIBITORS ON EFFICIENCY FOR SUPPRESSION OF PROTEOLYTIC ACTIVATION OF PNEUMONIA
A.V. Kubyshkin, I.I. Fomochkina
The Crimea State Medical University, Simferopol, Ukraine
DOI: https://doi.org/10.15407/fz55.01.043
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Abstract
We studied the influence of a way of introduction proteinase inhibitors on efficiency of suppression of proteolysis activation during pneumonia. Comparative study of efficiency of proteases inhibition in experimental pneumonia has shown higher efficacy of local introduction of drugs. Intravenous and intraperitoneal introduction of proteinase inhibitors exhibited inhibitory effect of a smaller degree on local and systemic proteases activation, did not decrease an acute phase of response of a-1-protease inhibitor in comparison with endotracheal instillation of Contrycal and Ingiprol. The study has established that endotracheal introduction of proteinase inhibitors is the most effective for correction of the proteinase-inhibitor balance. It also helps to promote the activity proteinase-inhibitor, suppresses elastolytic activity, decreases cellular infiltration, reduces the concentration of proteins in bronco-alveolar lavage fluid that is connected with address delivery of drugs to the target organ creating a maximal concentration of drugs in affected area.
Keywords:
proteinase inhibitors
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