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ISSN 2522-9028 (Print)
ISSN 2522-9036 (Online)
DOI: https://doi.org/10.15407/fz

Fiziologichnyi Zhurnal

is a scientific journal issued by the

Bogomoletz Institute of Physiology
National Academy of Sciences of Ukraine

Editor-in-chief: V.F. Sagach

The journal was founded in 1955 as
1955 – 1977 "Fiziolohichnyi zhurnal" (ISSN 0015 – 3311)
1978 – 1993 "Fiziologicheskii zhurnal" (ISSN 0201 – 8489)
1994 – 2016 "Fiziolohichnyi zhurnal" (ISSN 0201 – 8489)
2017 – "Fiziolohichnyi zhurnal" (ISSN 2522-9028)

Fiziol. Zh. 2009; 55(1): 43-48


THE INFLUENCE OF INTRODUCTION OF PROTEINASE INHIBITORS ON EFFICIENCY FOR SUPPRESSION OF PROTEOLYTIC ACTIVATION OF PNEUMONIA

A.V. Kubyshkin, I.I. Fomochkina

    The Crimea State Medical University, Simferopol, Ukraine
DOI: https://doi.org/10.15407/fz55.01.043

Abstract

We studied the influence of a way of introduction proteinase inhibitors on efficiency of suppression of proteolysis activation during pneumonia. Comparative study of efficiency of proteases inhibition in experimental pneumonia has shown higher efficacy of local introduction of drugs. Intravenous and intraperitoneal introduction of proteinase inhibitors exhibited inhibitory effect of a smaller degree on local and systemic proteases activation, did not decrease an acute phase of response of a-1-protease inhibitor in comparison with endotracheal instillation of Contrycal and Ingiprol. The study has established that endotracheal intro­duction of proteinase inhibitors is the most effective for correction of the proteinase-inhibitor balance. It also helps to promote the activity proteinase-inhibitor, suppresses elastolytic activity, de­creases cellular infiltration, reduces the concentration of pro­teins in bronco-alveolar lavage fluid that is connected with ad­dress delivery of drugs to the target organ creating a maximal concentration of drugs in affected area.

Keywords: proteinase inhibitors

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