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ISSN 2522-9028 (Print)
ISSN 2522-9036 (Online)
DOI: https://doi.org/10.15407/fz

Fiziologichnyi Zhurnal

is a scientific journal issued by the

Bogomoletz Institute of Physiology
National Academy of Sciences of Ukraine

Editor-in-chief: V.F. Sagach

The journal was founded in 1955 as
1955 – 1977 "Fiziolohichnyi zhurnal" (ISSN 0015 – 3311)
1978 – 1993 "Fiziologicheskii zhurnal" (ISSN 0201 – 8489)
1994 – 2016 "Fiziolohichnyi zhurnal" (ISSN 0201 – 8489)
2017 – "Fiziolohichnyi zhurnal" (ISSN 2522-9028)

Fiziol. Zh. 2009; 55(1): 12-18


EARLY DIAGNOSTICS OF ISCHEMIC DAMAGES OF THE MYOCARDIUM BY MEANS OF THE MARKER OF OPENING THE MITOCHONDRIAL PORE

V. F. Sagach1, A.V. Dmitrieva1, J.A. Bubnova1, V.B. Maksimenko2, G.V. Knyshov2

  1. O.O. Bogomoletz Institute of Physiology National Academy Sciences of Ukraine, Kyiv, Ukraine
  2. M.M. Amosov Institute Surgery Academy Medical Sciencesof Ukraine, Kyiv, Ukraine
DOI: https://doi.org/10.15407/fz55.01.012

Abstract

In the article a possibility of definition of level of the mitochon-drial factor (MF) for early diagnostics of the myocardial is chemic damages at patients during heart surgery was investigated. The reperfusion damages of heart were manifested by MPTP activation and MF release. The rising of MF level during a cardioplegia is comparable to level, which has been noted at patients with angina before operation of aorto-coronary shunting. The beginning of reperfusion, practically did not change MF level, but 5 minutes after restoration of a blood flow and warm reductions it increased to the maximum values. Thus, it closely correlated with a level of a myocardial contractility de­pression and data of biochemical researches, which are tradi­tionally used in clinic for diagnostics of damages of a heart. It allows to confirm, what exactly reperfusion is a major factor damaging of a myocardium. Its important that, change of MF level we registered at first minutes of heart reperfusion, those are much earlier, than by means of other markers. It seems to us, that investigation of a MF is very perspective for early find­ing of an ischemic damages of different tissues and organs.

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