Efficacy of immunoadsorbentin experimental allergicencephalomyelitis
N.M. Gurina, K.I. Bardakhivska,T.M. Kuchmerovska.
R.E.Kavetsky Institute of Experimental Pathology,Oncology & Radiobiology, National Academy of Sciencesof Ukraine, Kyiv;O.V.Palladin Institute of Biochemistry, National Academyof Sciences of Ukraine, Kyiv
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Abstract
Hemoperfusion through the granulated hemoadsorbent SCN,
fibrous carbonic adsorbent AUVM and immunoadsorbent (SCN
with immobilized MBP) was applied for the treatment of ex-
perimental allergic encephalomyelitis (EAE) in guinea pigs. EAE
was induced by single subcutaneous injection of 100 µg of MBP
in complete Freund’s adjuvant. Hemoperfusion was performed
on the stage of EAE manifestation or in latent period. It was
found that immunoadsorbent has the highest therapeutic effi-
cacy and allows to eliminate up to 32% anti-MBP antibodies
from the serum of guinea pigs with EAE, has up to 84% and
90% of adsorptive capacity of small and middle weight endog-
enous substances, respectively, and reduces the level of me-
tabolites with molecular weight less than 30 kDa in blood plasma
up to 36% .
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