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ISSN 2522-9028 (Print)
ISSN 2522-9036 (Online)
DOI: https://doi.org/10.15407/fz

Fiziologichnyi Zhurnal

is a scientific journal issued by the

Bogomoletz Institute of Physiology
National Academy of Sciences of Ukraine

Editor-in-chief: V.F. Sagach

The journal was founded in 1955 as
1955 – 1977 "Fiziolohichnyi zhurnal" (ISSN 0015 – 3311)
1978 – 1993 "Fiziologicheskii zhurnal" (ISSN 0201 – 8489)
1994 – 2016 "Fiziolohichnyi zhurnal" (ISSN 0201 – 8489)
2017 – "Fiziolohichnyi zhurnal" (ISSN 2522-9028)

Fiziol. Zh. 2008; 54(6): 79-86


Efficacy of immunoadsorbentin experimental allergicencephalomyelitis

N.M. Gurina, K.I. Bardakhivska,T.M. Kuchmerovska.

    R.E.Kavetsky Institute of Experimental Pathology,Oncology & Radiobiology, National Academy of Sciencesof Ukraine, Kyiv;O.V.Palladin Institute of Biochemistry, National Academyof Sciences of Ukraine, Kyiv


Abstract

Hemoperfusion through the granulated hemoadsorbent SCN, fibrous carbonic adsorbent AUVM and immunoadsorbent (SCN with immobilized MBP) was applied for the treatment of ex- perimental allergic encephalomyelitis (EAE) in guinea pigs. EAE was induced by single subcutaneous injection of 100 µg of MBP in complete Freund’s adjuvant. Hemoperfusion was performed on the stage of EAE manifestation or in latent period. It was found that immunoadsorbent has the highest therapeutic effi- cacy and allows to eliminate up to 32% anti-MBP antibodies from the serum of guinea pigs with EAE, has up to 84% and 90% of adsorptive capacity of small and middle weight endog- enous substances, respectively, and reduces the level of me- tabolites with molecular weight less than 30 kDa in blood plasma up to 36% .

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