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Calcium-dependent mechanismsof the disorders of stressand noradrenergic responsesof hypothalamo–pituitary-adrenalsystem in neonatally androgenizedfemale rats
A.G. Reznikov, N.D. Nosenko, P.V. Sinitsyn.
V.P. Komissarenko Institute of Endocrinologyand Metabolizm AMS of Ukraine
Abstract
he effects of neonatal administration of verapamil, a calcium
L-type channel blocker, on the stress and noradrenergic
responses of hypothalamo-pituitary-adrenal (HPA) axis in adult
female rats with anovulatory syndrome induced by neonatal
androgenization have been studied. There was no adrenocorti-
cal response to an acute stress nor noradrenaline infusion in the
3rd brain ventricle in females with persistent estrus. Verapamil
pretreatment completely restored the adrenocortical responses
to normal level. No changes were found in studied parameters
following treatment with verapamil alone. These results dem-
onstrate possible involvement of calcium signalling in pathogen-
esis of the disorders of HPA function in adult female rats, in-
duced by neonatal androgenization.
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