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ISSN 2522-9028 (Print)
ISSN 2522-9036 (Online)
DOI: https://doi.org/10.15407/fz

Fiziologichnyi Zhurnal

is a scientific journal issued by the

Bogomoletz Institute of Physiology
National Academy of Sciences of Ukraine

Editor-in-chief: V.F. Sagach

The journal was founded in 1955 as
1955 – 1977 "Fiziolohichnyi zhurnal" (ISSN 0015 – 3311)
1978 – 1993 "Fiziologicheskii zhurnal" (ISSN 0201 – 8489)
1994 – 2016 "Fiziolohichnyi zhurnal" (ISSN 0201 – 8489)
2017 – "Fiziolohichnyi zhurnal" (ISSN 2522-9028)

Fiziol. Zh. 2008; 54(6): 24-29


Calcium-dependent mechanismsof the disorders of stressand noradrenergic responsesof hypothalamo–pituitary-adrenalsystem in neonatally androgenizedfemale rats

A.G. Reznikov, N.D. Nosenko, P.V. Sinitsyn.

    V.P. Komissarenko Institute of Endocrinologyand Metabolizm AMS of Ukraine


Abstract

he effects of neonatal administration of verapamil, a calcium L-type channel blocker, on the stress and noradrenergic responses of hypothalamo-pituitary-adrenal (HPA) axis in adult female rats with anovulatory syndrome induced by neonatal androgenization have been studied. There was no adrenocorti- cal response to an acute stress nor noradrenaline infusion in the 3rd brain ventricle in females with persistent estrus. Verapamil pretreatment completely restored the adrenocortical responses to normal level. No changes were found in studied parameters following treatment with verapamil alone. These results dem- onstrate possible involvement of calcium signalling in pathogen- esis of the disorders of HPA function in adult female rats, in- duced by neonatal androgenization.

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