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ISSN 2522-9028 (Print)
ISSN 2522-9036 (Online)
DOI: https://doi.org/10.15407/fz

Fiziologichnyi Zhurnal

is a scientific journal issued by the

Bogomoletz Institute of Physiology
National Academy of Sciences of Ukraine

Editor-in-chief: V.F. Sagach

The journal was founded in 1955 as
1955 – 1977 "Fiziolohichnyi zhurnal" (ISSN 0015 – 3311)
1978 – 1993 "Fiziologicheskii zhurnal" (ISSN 0201 – 8489)
1994 – 2016 "Fiziolohichnyi zhurnal" (ISSN 0201 – 8489)
2017 – "Fiziolohichnyi zhurnal" (ISSN 2522-9028)

Fiziol. Zh. 2008; 54(6): 15-23


Cardioprotective effectsof flokalin: relative role of activa-tion of sarcolemmal and mitochon-drial of katp channels

R.B. Strutynskyi, S.N. Pyvovar, L.V. Tumanovs’ka,A.A.Moibenko.

    O.O.Bogomoletz Institute of Physiology, NationalAcademy of Sciences of Ukraine, Kyiv


Abstract

In experiments on isolated Langendorff perfused hearts of guinea pig with modeling of ischemia (20 min) and reperfusion (40 min) the cardioprotective effects of flokalin were shown. Preliminary preischemic perfusion of isolated heart with flokalin (5 мM) for 5 minutes has significantly improved the recovery of contractive function of ischemic myocardium at reperfusion. Particularly, recovery of systolic and developed pressure was improved and the increasing of end-diastolic pressure in left ventricle was prevented. The vasoconstriction of coronary ves- sels was prevented and number of extrasystols at reperfusion of ischemic heart was decreased. Morphological studies have shown that flokalin prevents the significant damage of myocar- dial structure and the development of hypercontraction of myofibrils at ischemia-reperfusion of myocardium. It also pre- serves the intact sarcolemma and intracellular organelles. The intact structure of mitochondria also was saved by flokalin that maintains the energy potential of myocardium. Using the selec- tive blocker of mitochondrial KATP channels 5-hydroxydecanoate (200 мM) allows to determine the relative role of sarcolemmal and mitochondrial KATP channels activation in these effects. It was shown that mitochondrial as well as sarcolemmal KATP channels play role in the recovery of ischemic myocardium func- tions: first are responsible for recovery of contractive function and second are responsible for coronary blood flow recovery.

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