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ISSN 2522-9028 (Print)
ISSN 2522-9036 (Online)
DOI: https://doi.org/10.15407/fz

Fiziologichnyi Zhurnal

is a scientific journal issued by the

Bogomoletz Institute of Physiology
National Academy of Sciences of Ukraine

Editor-in-chief: V.F. Sagach

The journal was founded in 1955 as
1955 – 1977 "Fiziolohichnyi zhurnal" (ISSN 0015 – 3311)
1978 – 1993 "Fiziologicheskii zhurnal" (ISSN 0201 – 8489)
1994 – 2016 "Fiziolohichnyi zhurnal" (ISSN 0201 – 8489)
2017 – "Fiziolohichnyi zhurnal" (ISSN 2522-9028)

Fiziol. Zh. 2008; 54(5): 55-60

Functional andmolecular changes of bkca channels in rat aortic smooth muscle cellsafter ionizing irradiation

S.V. Kyrychenko, S.M. Tishkin, V.E. Dosenko, O.O. Moybenko, A.I. Soloviev.

    ДУ «Ін-т фармакології та токсикології АМН України»,Київ;Ін-т фізіології ім. О.О. Богомольця НАН України, Київ



Abstract

The aim of the study was to investigate the pattern of lipid and lipoprotein metabolism disturbances in patients with manifested clinical signs of coronary atherosclerosis. There was determined the significance of hypertrigliceridemia as the marker of these disturbances and its connection with other most important factors of atherogenesis such as insulin resistance, systemic inflammation, and oxidative stress, blood lipoprotein modification. The role of excessive alimentary lipid consumption as a factor, which initiates the hypertrigliceridemia development and accompanying activation of the other proatherogenic factors was determined with the use of acute lipid loading. It was established that hypertrigliceridemia is one of the most reliable signs of atherosclerosis existence but it coincides as a rule with other signs of dislipidemia, a decrease in insulin sensitivity, systemic inflammation and lipid free radical oxidation development. The modification of blood lipoprotein and increase of blood atherogenic potentials were the integral effects of these factors. Significance of hypertrigliceridemia as the factor initiating all these distur- bances both in normal volunteers and in examined patients was shown in conditions of acute lipid loading which was accompanied by the development of the whole complex of proatherogenic disturbances. It was established that the devel- opment of atherosclerosis is connected with the decrease of lipid tolerance and as a result the same lipid loading was ac- companied with proportional increase of both hyper- trigliceridemia and connected with it proatherogenic distur- bances. The obtained data allowed concluding that hyper- trigliceridemia is the factor which can initiate the proatherogenic systemic disturbances which include changes in lipid, lipoprotein and glucose metabolism, the development of insulin resistance, systemic inflammation and oxidative stress. These changes are pathogenically interconnected, capable to amplify one another and induce blood lipoprotein modification with appearance of both proatherogenic and autoantigenic propertries, which stipulate the role of hypertrigliceridemia in atherogenesis.

Full text: (PDF, in Ukrainian)

References

  1. Аронов Д.М. Лечение и профилактика атеро- склероза. – М.: Триада-Х, 2000. – 412 с.
  2. Талаева Т.В., Корниенко О.В., Братусь В.В. и др. Атерогенная модификация липопротеинов крови и гиперхолестеринемия как следствия острого воспа- лительного процесса //Журн. АМН Украины. – 1997. – 3, № 3. – С.463–471.
  3. Adiels M., Borйn J., Caslake M.J. et al. Overproduc- tion of VLDL 1.diven by hуperglycemia is a dominant feature of diabetic dyslipidemia // Arterioscler. Thromb. Vasc. Biol. – 2005. – 25. – P.11697–1705.
  4. Aljada A., Mohanty P., Ghanim H. et al. Increase in intranuclear nuclear factor kappaB and decrease in in- hibitor kappaB in mononuclear cells after a mixed meal: evidence for a proinflammatory effect // Amer. J.Clin. Nutr. – 2004. – 79. – P.682–690.
  5. Assman G., Gotto A.M. HDL cholesterol and protec- tive factors in atherosclerosis //Circulation. – 2004. – 109, suppl.III. – P.III-8–III-14.
  6. Austin M.A. Epidemiology of hypertrigliceridemia and cardiovascular disease // Amer. J.Cardiol. – 1999. – 83. – P.13F–16F.
  7. Chirieac D.V., Collins H.L., Cianci J.et al. Altered trig- lyceride-rich lipoprotein production in Zucker diabetic fatty rats // Amer. J.Physiol. Endocrinol. Metab. –2004. – 287. – P.E42–E49.
  8. Clapp B.R., Hingorani A.D., Kharbanda R.K. et al. Inflammation-induced endothelial dysfunction involves reduced nitric oxide bioavailability and increased oxi- dant stress // Cardiovascular. Res. – 2004. – 64. – P.172–178.
  9. 9.Day C. Diagnostic definitions-metabolic syndrome // Brit. J.Diab. Vasc. Dis. –2005. – 5. – P.115–118.
  10. 10.Festa A., D’Agostino R., Howard G.et al. Chronic sub- clinical inflammation as part of the insulin resistance syndrome: the Insulin Resistance Atherosclerosis Study (IRAS) // Circulation. – 2000. – 102. – P.42–47.
  11. Laight DW, Carrier MJ, Anggard EE. Antioxidants, dia- betes and endothelial dysfunction // Cardiovascular. Res. – 2000. – 47. – P.457–464.
  12. Merkel M., Eckel R.H., Goldberg I.J. Lipoprotein lipase: genetics, lipid uptake, and regulation // J.Lipid Res. – 2002. – 43. – Р.1997–2006.
  13. Miller G.J.Dietary fatty acids and the haemostatic sys- tem // Atherosclerosis. –2005. – 179, № 2. – P.213–227.
  14. Pilz S., Scharnagl H., Tiran B. et al. Free fatty acids are independently associated with all-cause and cardio- vascular mortality in subjects with coronary artery disease // J.Clin. Endocrinol. and Metabol. – 2005. – 91, № 7. – P.2542–2547.
  15. Raghavan R.P., Laight D.W., Shaw K.M., Cummings M.H. Aspirin and diabetes // Br.J.Diabetes Vasc.Dis. – 2006. – 6, № 2. – P.74–82.
  16. Shoelson S.E., Lee J., Goldfine A.B. Inflammation and insulin resistance // J.Clin. Invest. – 2006. – 116. – P.1793–1801.
  17. Smith S.R., Wilson P.W.F. Free fatty acids and athero- sclerosis-guilty or innocent? // J.Clin. Endocrinol. and Metabol. – 2006. – 91, № 7. – P. 2506–2508.
  18. Stern M.P. Diabetes and cardiovascular disease. The «common soil» hypothesis // Diabetes. – 1995. – 44. – P.369–374. В.В.Амброскіна, Т.А.Крячок, О.П. Ларіонов, В.В.Братусь, Т.В.Талаєва
  19. 07ISSN 0201-8489 Фізіол. журн., 2008, Т. 54, № 5 ННЦ І-т кардіології ім. М.Д. Стражеска АМН України, Київ victorbratus@yahoo.com Матеріал надійшов до редакції 29.10.2007
  20. 19.Valabhji J., Elkeles R.S. Dyslipidemia in type 2 diabetes: epidemiology and biochemistry // Br.J.Diabetes Vasc.Dis. – 2003. – 3, № 3. – P.184–189.
  21. 20.Vogel R.A., Corretti M.C., Plotnick G.D. Effect of a single high-fat meal on endothelial function in healthy subjects // Amer. J.Cardiol. – 1997. – 79. – P.350–354.
  22. Weisberg S.P., Hunter D., Huber R.et al. CCR2 modu- lates inflammatory and metabolic effects of high-fat feeding // J.Clin. Invest. – 2006. – 116. – P.115–124.
  23. Zheng C., Murdoch S.J., Brunzell J.D., Sacks F.M. Lipoprotein lipase bound to apolipoprotein B lipoproteins accelerates clearance of postprandial lipoproteins in humans // Arterioscler. Thromb. Vasc. mBiol. – 2006. – 26. – P.891–899.
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