Functional andmolecular changes of bkca channels in rat aortic smooth muscle cellsafter ionizing irradiation
S.V. Kyrychenko, S.M. Tishkin, V.E. Dosenko, O.O. Moybenko, A.I. Soloviev.
ДУ «Ін-т фармакології та токсикології АМН України»,Київ;Ін-т фізіології ім. О.О. Богомольця НАН України, Київ
Abstract
The aim of the study was to investigate the pattern of lipid
and lipoprotein metabolism disturbances in patients with
manifested clinical signs of coronary atherosclerosis. There
was determined the significance of hypertrigliceridemia as the
marker of these disturbances and its connection with other
most important factors of atherogenesis such as insulin
resistance, systemic inflammation, and oxidative stress, blood
lipoprotein modification. The role of excessive alimentary lipid
consumption as a factor, which initiates the hypertrigliceridemia
development and accompanying activation of the other
proatherogenic factors was determined with the use of acute
lipid loading. It was established that hypertrigliceridemia is
one of the most reliable signs of atherosclerosis existence but it
coincides as a rule with other signs of dislipidemia, a decrease
in insulin sensitivity, systemic inflammation and lipid free
radical oxidation development. The modification of blood
lipoprotein and increase of blood atherogenic potentials were
the integral effects of these factors. Significance of
hypertrigliceridemia as the factor initiating all these distur-
bances both in normal volunteers and in examined patients
was shown in conditions of acute lipid loading which was
accompanied by the development of the whole complex of
proatherogenic disturbances. It was established that the devel-
opment of atherosclerosis is connected with the decrease of
lipid tolerance and as a result the same lipid loading was ac-
companied with proportional increase of both hyper-
trigliceridemia and connected with it proatherogenic distur-
bances. The obtained data allowed concluding that hyper-
trigliceridemia is the factor which can initiate the proatherogenic
systemic disturbances which include changes in lipid,
lipoprotein and glucose metabolism, the development of insulin
resistance, systemic inflammation and oxidative stress. These
changes are pathogenically interconnected, capable to amplify
one another and induce blood lipoprotein modification with
appearance of both proatherogenic and autoantigenic
propertries, which stipulate the role of hypertrigliceridemia in
atherogenesis.
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