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ISSN 2522-9028 (Print)
ISSN 2522-9036 (Online)
DOI: https://doi.org/10.15407/fz

Fiziologichnyi Zhurnal

is a scientific journal issued by the

Bogomoletz Institute of Physiology
National Academy of Sciences of Ukraine

Editor-in-chief: V.F. Sagach

The journal was founded in 1955 as
1955 – 1977 "Fiziolohichnyi zhurnal" (ISSN 0015 – 3311)
1978 – 1993 "Fiziologicheskii zhurnal" (ISSN 0201 – 8489)
1994 – 2016 "Fiziolohichnyi zhurnal" (ISSN 0201 – 8489)
2017 – "Fiziolohichnyi zhurnal" (ISSN 2522-9028)

Fiziol. Zh. 2008; 54(5): 40-45


Effects of isoflurane on hippocampal seizures at immature rats in vivo

E. V. Lsaeva.

    O.O.Bogomoletz Institute of Physiology, Kyiv, Ukraine


Abstract

In the present study we examined the effect of isoflurane on seizure-like activity at hippocampal CA3 pyramidal region of immature rats in vivo. We found that isoflurane in clinically relevant concentrations effectively stops hippocampal sei- zures. When animal was under isoflurane anesthesia seizure- like activity still can be evoked by application of procon- vulstant agents, but this activity was qualitatively different from that obtained in nonanesthetized rats. This observation suggests that the mechanism by which seizures are terminated differ from the mechanism responsible for preventing of the initiation of seizures.

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