Prenatal dexamethasoneprevents early and long-lasting neuroendocrine and behavioral effects ofmaternal stress on male offspring
A.G. Reznikov, N.D. Nosenko, L.V. Tarasenko, P.V. Sinitsyn, A.A. Lymareva.
V.P.Komisarenko Institute of Endocrinology and Metabolism, Kyiv
Abstract
The hypothesis on the mediating role of hypothalamic-pitu-
itary-adrenocortical (HPA) hormone secretion in neuroendo-
crine, neurochemical and behavioral alterations generated by
prenatal stress in male rat offspring was tested in this study
with dexamethasone (Dex) used for suppression of HPA stress
responses. Pregnant dams were being restrained daily for 1 h
over the last week of gestation. In male offspring this resulted
in attenuation of sex-specific pattern of the protein fractions
(on the 5th postnatal day), steroid aromatase activity (on the
10th postnatal day) in the brain preoptic area, and in a decrease
of male copulatory behavior, hypothalamic noradrenaline and
plasma corticosterone responses to an acute stress, an increase
in HPA responses to noradrenergic stimulation and other ef-
fects in adulthood. All those changes were prevented with
prenatal Dex in a dose of 0.1 mg/kg b.w. injected 30 min prior
to restraining pregnant dams. As such, HPA hormone secre-
tion mediates alterations of programming of brain develop-
ment induced by prenatal stress.
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