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ISSN 2522-9028 (Print)
ISSN 2522-9036 (Online)
DOI: https://doi.org/10.15407/fz

Fiziologichnyi Zhurnal

is a scientific journal issued by the

Bogomoletz Institute of Physiology
National Academy of Sciences of Ukraine

Editor-in-chief: V.F. Sagach

The journal was founded in 1955 as
1955 – 1977 "Fiziolohichnyi zhurnal" (ISSN 0015 – 3311)
1978 – 1993 "Fiziologicheskii zhurnal" (ISSN 0201 – 8489)
1994 – 2016 "Fiziolohichnyi zhurnal" (ISSN 0201 – 8489)
2017 – "Fiziolohichnyi zhurnal" (ISSN 2522-9028)

Fiziol. Zh. 2008; 54(5): 23-27

Potentiation of c-fosexpression in the spinal cord initiated by the signals from fatigue skeletal muscles

O.I. Pilyavskii, A.V. Maznychenko, V.O. Maisky, O.I. Kostyukov.

    Ін-т фізіології ім. О.О. Богомольця НАН України, Київ



Abstract

Immunohistochemical studies of с-fos expression in the lumbar and neck segments of spinal cord after fatiguing stimulation of the mm. gastrocnemius-soleus or m. trapezius and m. splenius, were carried out on the anaesthetized (chloral-hydrate 400 mg/ kg, i.p.) rats. The patterns of the Fos-immunoreactive neurons distribution in the grey matter of spinal cord in the L4 and L5 segments, as well as the C2 and C3 were similar. The highest number of marked cells was registered in the dorsal horn in the first, fourth and fifth layers of grey matter, i.e. within the areas of termination of high-threshold muscle afferents of group ІІІ and ІV. It is assumed, that the types of afferents could be acti- vated by muscle fatigue-induced metabolites. The signals in- coming to the spinal cord could be involved into the presynaptic inhibition of muscle spindle volleys than resulted in the impairment of motor output performance. This mechanism is substantial for limitation of the force of muscles contraction and prevention the injury of the muscles under the excessive physical loading.

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