Potentiation of c-fosexpression in the spinal cord initiated by the signals from fatigue skeletal muscles
O.I. Pilyavskii, A.V. Maznychenko, V.O. Maisky, O.I. Kostyukov.
Ін-т фізіології ім. О.О. Богомольця НАН України, Київ
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Abstract
Immunohistochemical studies of с-fos expression in the lumbar
and neck segments of spinal cord after fatiguing stimulation of
the mm. gastrocnemius-soleus or m. trapezius and m. splenius,
were carried out on the anaesthetized (chloral-hydrate 400 mg/
kg, i.p.) rats. The patterns of the Fos-immunoreactive neurons
distribution in the grey matter of spinal cord in the L4 and L5
segments, as well as the C2 and C3 were similar. The highest
number of marked cells was registered in the dorsal horn in the
first, fourth and fifth layers of grey matter, i.e. within the areas
of termination of high-threshold muscle afferents of group ІІІ
and ІV. It is assumed, that the types of afferents could be acti-
vated by muscle fatigue-induced metabolites. The signals in-
coming to the spinal cord could be involved into the presynaptic
inhibition of muscle spindle volleys than resulted in the impairment
of motor output performance. This mechanism is substantial for
limitation of the force of muscles contraction and prevention
the injury of the muscles under the excessive physical loading.
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