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ISSN 2522-9028 (Print)
ISSN 2522-9036 (Online)
DOI: https://doi.org/10.15407/fz

Fiziologichnyi Zhurnal

is a scientific journal issued by the

Bogomoletz Institute of Physiology
National Academy of Sciences of Ukraine

Editor-in-chief: V.F. Sagach

The journal was founded in 1955 as
1955 – 1977 "Fiziolohichnyi zhurnal" (ISSN 0015 – 3311)
1978 – 1993 "Fiziologicheskii zhurnal" (ISSN 0201 – 8489)
1994 – 2016 "Fiziolohichnyi zhurnal" (ISSN 0201 – 8489)
2017 – "Fiziolohichnyi zhurnal" (ISSN 2522-9028)

Fiziol. Zh. 2008; 54(5): 16-22


Integrative function of nervous cells:role of potassium channels

I.S. Magura, E.V. Dolgaya, N.A. Bogdanova.

    Ін-т фізіології ім. О.О. Богомольця НАН України, Київ


Abstract

Complex processing and integration of the signals observed in neurons are facilitated by a diverse range of the gating proper- ties of the ion channels in this cell type, particularly of the voltage-gated potassium channels. A distinctive combination of potassium channels endows neurons with a broad repertoire of the excitable properties and allows each neuron to respond in a specific manner to a given input at a given time. The properties of many potassium channels can be modulated by second messenger pathways activated by neurotransmitters and other stimuli. Potassium channels are among the most frequent targets of the actions of several signaling systems.

References

  1. СПИСОК ЛІТЕРАТУРИ
  2. Магура И.С. Молекулярные механизмы модуляции интегративной функции нервных клеток: роль калиевых каналов// Арх. клинич. и эксперим. – 2002. – 11, № 1. – C.7–9.
  3. Серков Ф.Н. Электрофизиология высших отделов слуховой системы. – К.: Наук. думка, 1977. – 216 с.
  4. Серков Ф.Н., Казаков В.Н. Нейрофизиология таламуса. – К.: Наук. думка, 1980–260 с.
  5. Breitwieser G. E. Mechanisms of K+ channel regulation Membrane Biol. – 1996. – 152. – P.1–11.
  6. Butler A., Wei A.G., Baker K., Salkoff L. A family of putative potassium channel genes in Drosophila // Sci- ence. – 1989. – 243. – P.943–947.
  7. Choe S. Potassium channel structures // Nature Rev. – 2002. – 3. – P.118–121.
  8. Conforti L., Millhorn D. E. Selective inhibition of a slow- inactivating voltage-dependent K+ channel in rat PC12 cells by hypoxia // J. Physiol. – 1997. – 502. – P.293–305.
  9. Connor J.A., Stevens C.F. Inward and delayed outward membrane currents in isolated neural somata under volt- age clamp // Ibid. – 1971 – 213. – P.1–19.
  10. 9. Connor J.A., Stevens С.F. Voltage clamp studies of a transient outward membrane current in gastropod neu- ral somata // Ibid. – 1971 – 213. – P.21–30.
  11. 10. Connor J.A., Stevens С.F. Prediction of repetitive fir- ing behavior from voltage clamp data on an isolated neurone soma // Ibid. – 1971 – 213. – P.31–53.
  12. Franks N.P., Honore E. The TREK K 2P channels and their role in general anaesthesia and neuroprotection // Trends Pharmacol. Sci. – 2004. – 25. – P.601–608.
  13. Gan L., Hahn S.J., Kaczmarek L.K. Cell type-specific expression of the Kv3.1 gene is mediated by a negative element in the 5' untranslated region of the Kv3.1 pro- moter // J. Neurochem. – 1999. – 73. – P.1350–1362.
  14. Hille B. Ionic Channels of Excitable Membrane // Sinauer Assoc, Sunderland, Massachusetts. – 1992.
  15. Hwang P.G., Glatt С.E., Bredt D.S. et al. A novel K+ channel with unique localizations in mammalian brain: molecular cloning and characterization // Neuron. – 1992. – 8. – P.473–481.
  16. Isom L.L., DeJongh K.S., Catterall W.A. Auxiliary sub- units of voltage-gated ion channels // Ibid. – 1994. – 12. – P.1183–1194.
  17. Johnston D., Hoffman D.A., Magee J.С. et al. Den- dritic potassium channels in hippocampal pyramidal neurons // J. Physiol. – 2000. – 525. – P.75–81.
  18. Kiss L., LoTurco J., Korn S.J. Contribution of the se- lectivity filter to inactivation in potassium channels // Biophys. – 1999. – 16. – P.253–263.
  19. Li Y., Um S.Y., McDonald T.V. Voltage-gated potas- sium channels: regulation by accessory subunits // Neuroscientist. – 2006. – 12. – P.199–210.
  20. 19. MacKinnon R. Potassium channels // FEBS Lett. – 2003. – 555. – P.62–65.
  21. 20. Martens J.R., O’Connell K., Tamkun M. Targeting of ion channels to membrane microdomains: localization of Kv channels to lipid rafts // Trends Pharmacol. Sci. – 2004. – 25. – P.16–21.
  22. Miller С. An overview of the Potassium channel family Genome Biol. – 2000. – 1. – P.0004.1–0004.5.
  23. Nilius В., Droogmans G. A role for K+ channels in cell proliferation // NIPS. – 1994. – 9. – P.105–110.
  24. Рак M.D., Baker К., Covarrubias M. et al. mShal, a subfam- ily of A-type K+ channel cloned from mammalian brain // Proc. Natl. Acad. Sci. USA. – 1991 – 88. – P.4386–4390.
  25. Рак M.D., Covarrubias М., Ratcliffe A., Salkoff L. A mouse brain homolog of the Drosophila Shab K+ channel with conserved delayed-rectifier properties // J. Neuro- sci. – 1991. – 11. – P.869–880.
  26. Papazian D.M., Tempel B.L., Schwarz T.L. et al. Cloning of genomic and complementary DNA from Shaker, a putative potassium channel gene from Droso- phila // Science. – 1987. – 237. – P.749–753.
  27. Perez-Garsia M.T., Lopez-Lopez J.R. Are Kv channels the essence of O 2 sensing // Circulat. Res. – 2000. – 86. – P.490–491. І.С. Магура, О.В. Долга, Н.О. Богданова
  28. 22ISSN 0201-8489 Фізіол. журн., 2008, Т. 54, № 5
  29. Salkoff L., Baker K., Butler A. et al. An essential «set» of K+ channels conserved in flies, mice and humans // Trends Neurosci. – 1995. – 18. – P.161–166.
  30. Semenza G.L. Perspectives on oxygen sensing // Cell. – 1999. – 98. – P.281–284.
  31. 29. Szewczyk A., Pikula S. Lipid metabolism as a target for potassium channel effectors // Biochem. Pharmacol. – 60. – P.607–614.
  32. 30. Tan Y.P., Llano I. Modulation by K+ channels of action potential-evoked intracellular Ca2+ concentration rises in rat cerebellar basket cell axons // J. Physiol. – 1999. – 520. – P.65–78.
  33. Тоrо L., Wallner М., Meera P., Tanaka Y. Maxi-KCa, a unique member of the voltage – gated К channel su- perfamily // News Physiol. Sci. – 1998. – 13. – P.112–117.
  34. Trimmer J.S. Expression of Kv2.1 delayed rectifier K+ channel isoforms in the developing rat brain // FEBS Lett. – 1993. – 324. – P.205–210.
  35. Yellen G. The moving parts of voltage-gated ion channels //Quart. Rev. Biophys. – 1998. – 31. – P.239–295.

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