The presence and character of interrelations between lipid metabolism disturbances andsystemic inflammation
V.V.Ambroskina, T.А.Kriachok, A.P.Larionov, T.V.Talaeva, V.V.Bratus.
NSC N.D. Strazhesko Institute of Cardiology”, UkrainianAcademy of Medical Sciences, Kyiv
Abstract
The aim of the investigation was to determine the existence
and describe interconnection between the lipid metabolism
disturbances and development of systemic inflammation. The
work was carried out on rabbits in two series of experiments:
in the first one, the model of inflammation was reproduced be
means of intravenous injection of bacterial lipopolysaccharide.
In the second one, the model of lipid disturbances induced by
lipids enriched diet was reproduced. In both series of experi-
ments, the indexes of inflammation and oxidative stress inten-
sity, metabolism of lipids and lipoproteins, insulin sensitivity,
blood lipoprotein proatherogenic and immunogenic modifica-
tion were determined. The data obtained confirmed the exist-
ence of distinct direct links between investigated influences:
during the primary induced inflammation we observed pro-
nounced disturbances in lipid and lipoprotein metabolism,
while under the primary induction of lipid disturbances the
systemic inflammation and oxidative stress were developed.
The connection between the action of both influences was
greatly mediated by their ability to induce insulin resistance.
There was also shown that the interrelation between these
factors is the cause of blood lipoprotein proatherogenic and
immunogenic modification, which is the main effector mecha-
nism of atherosclerosis development and progression.
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