Warning: include(phj2-admin/kernel/config.php): failed to open stream: No such file or directory in /zstorage3/vhosts/fz.kiev.ua/httpdocs/index.php on line 45

Warning: include(): Failed opening 'phj2-admin/kernel/config.php' for inclusion (include_path='.:/usr/local/share/pear') in /zstorage3/vhosts/fz.kiev.ua/httpdocs/index.php on line 45

Warning: Cannot modify header information - headers already sent by (output started at /zstorage3/vhosts/fz.kiev.ua/httpdocs/index.php:45) in /zstorage3/vhosts/fz.kiev.ua/httpdocs/kernel/content.php on line 3

Warning: array_unique() expects parameter 1 to be array, null given in /zstorage3/vhosts/fz.kiev.ua/httpdocs/kernel/content.php on line 77

Warning: Invalid argument supplied for foreach() in /zstorage3/vhosts/fz.kiev.ua/httpdocs/kernel/content.php on line 86
Fiziologichnyi Zhurnal - <a id="lj1_ret_bk_to_jl0_href_id" href="?list0=10">Fiziol. Zh. 2008;</a> <a id="lj1_ret_bk_to_jl0_href_id" href="?list1=48">54(3):</a> 36-46
Українська Русский English

ISSN 2522-9028 (Print)
ISSN 2522-9036 (Online)
DOI: https://doi.org/10.15407/fz

Fiziologichnyi Zhurnal

is a scientific journal issued by the

Bogomoletz Institute of Physiology
National Academy of Sciences of Ukraine

Editor-in-chief: V.F. Sagach

The journal was founded in 1955 as
1955 – 1977 "Fiziolohichnyi zhurnal" (ISSN 0015 – 3311)
1978 – 1993 "Fiziologicheskii zhurnal" (ISSN 0201 – 8489)
1994 – 2016 "Fiziolohichnyi zhurnal" (ISSN 0201 – 8489)
2017 – "Fiziolohichnyi zhurnal" (ISSN 2522-9028)

Fiziol. Zh. 2008; 54(3): 36-46


The presence and character of interrelations between lipid metabolism disturbances andsystemic inflammation

V.V.Ambroskina, T.А.Kriachok, A.P.Larionov, T.V.Talaeva, V.V.Bratus.

    NSC N.D. Strazhesko Institute of Cardiology”, UkrainianAcademy of Medical Sciences, Kyiv


Abstract

The aim of the investigation was to determine the existence and describe interconnection between the lipid metabolism disturbances and development of systemic inflammation. The work was carried out on rabbits in two series of experiments: in the first one, the model of inflammation was reproduced be means of intravenous injection of bacterial lipopolysaccharide. In the second one, the model of lipid disturbances induced by lipids enriched diet was reproduced. In both series of experi- ments, the indexes of inflammation and oxidative stress inten- sity, metabolism of lipids and lipoproteins, insulin sensitivity, blood lipoprotein proatherogenic and immunogenic modifica- tion were determined. The data obtained confirmed the exist- ence of distinct direct links between investigated influences: during the primary induced inflammation we observed pro- nounced disturbances in lipid and lipoprotein metabolism, while under the primary induction of lipid disturbances the systemic inflammation and oxidative stress were developed. The connection between the action of both influences was greatly mediated by their ability to induce insulin resistance. There was also shown that the interrelation between these factors is the cause of blood lipoprotein proatherogenic and immunogenic modification, which is the main effector mecha- nism of atherosclerosis development and progression.

References

  1. Ардаматский Н.А., Абакумова Ю.В. Настоящее и будущее профилактики атеросклероза // Между- нар.мед. журн. – 1999. – T. 3–4. – C. 149–152.
  2. Талаева Т.В., Корниенко О.В., Братусь В.В. и др. Атерогенная модификация липопротеинов крови и гиперхолестеринемия как следствия острого воспалительного процесса // Журн. АМН Укрaины. – 1997. – 3, № 3. – С.463–471.
  3. Berg A.H., Lin Y., Lisanti M.P., Scherer P.E. Adipocyte differentiation induces dynamic changes in NF-kB ex- pression and activity // Amer. J.Physiol. Endocrinol. and Metabol. – 2004. – 287. – P.E1178–E1188.В.В. Амброскіна, Т.A. Крячок, О.П. Ларіонов, В.В. Братусь, Т.В. Талаєва
  4. Blankenberg S., Luc G., Ducimetiere P.et al. Interleukin-18 and the risk of coronary heart disease in European men // Circulation. – 2003. – 108, № 20. – P. 2453–2439.
  5. Cominachini L., Garbin U., Pasini A.F.et al. Oxidized low-density lipoprotein increases the production of intracellular reactive oxygen species in endothelial cells:inhibitory effect of lacidipine // J.Hypertens. – 1998. –16. – P.1913–1919.
  6. Conraads V.M., Bosmans J.M., Schuerwegh A.J. et al. Association of lipoproteins with cytokines and cyto-kine receptors in heart failure patients // Europ.Heart J. – 2003. – 24, № 24. – P.2221–2226.
  7. Dichtl W, Nilsson L, Goncalves I et al. Very low den- sity lipoprotein activates nuclear factor-kB in endot- helial cells // Circulat. Res. – 1999. – 84, № 9. – P.1085–1094.
  8. Engstrom G. Stavenow L., Hedblad B. et al. Inflamma- tion-sensitive plasma proteins and incidence of myo- cardial infarction in men with low cardiovascular risk //Arterioscler. Thromb. Vascular. Biol. – 2003. – 23. –P.2247–2254.
  9. 9. Feingold K.R., Grunfeld C., Pang M. et al. LDL sub- class phenotypes and triglyceride metabolism in non- insulin-dependent diabetes mellitus // Ibid. – 1992. –12. – P.1496–1502.
  10. 10. Giannattasio C., Zoppo A., Gentile G. et al. Acute effect of high-fat meal on endothelial function in mod-erately dyslipidemic subjects // Ibid. – 2005. – 25. –P.406–412.
  11. Kharbanda R.K., Wallace S., Walton B. et al. Systemic acyl-CoA: cholesterol acyltransferase inhibition reduces inflammation and improves vascular function in hypercholesterolemia // Circulation. – 2005. – 111. –P.804–807.
  12. Khovidhunkit W., Memon R.A., Feingold K.R., Grunfeld C. Infection and inflammation-induced proatherogenic changes of lipoproteins // J. Infect Dis. – 2000. – 181 (Suppl 3). – Р. S462–S472.
  13. Li D., Singh R.M., Liu L. et al. Oxidized-LDL through LOX-1 increases the expression of angiotensin-converting enzyme in human coronary artery endothelial cells // Cardiovascular. Res. – 2003. – 57, № 1. – P.238–243.
  14. Mohrschladt M.F., Weverling-Rijnsburger A.W.E., de Man F.H.A.F. et al. Hyperlipoproteinemia affects cytokine production in whole blood samples ex vivo.The influence of lipid-lowering therapy // Atheroscle-rosis. – 1999. – 148, №2. – .P.413–419.
  15. Natarajan R., Nadler J.L. Lipid inflammatory media- tors in diabetic vascular disease // Аrterioscler. Thromb. Vascular. Biol. – 2004. – 24. – P.1542–1548.
  16. Rauchhaus M., Koloczek V., Volk H. et al. Inflamma- tory cytokines and the possible immunological role for lipoproteins in chronic heart failure // Int. J. Cardiol. –2000. – 76. – P.125–133.
  17. Ross R. Atherosclerosis – an inflammatory disease // N. Engl. J. Med. – 1999. – 340. – P.115–126.
  18. Stoll L.L., Denning G.M., Weintraub N.L. Potential
  19. 64ISSN role of endotoxin as a proinflammatory mediator of atherosclerosis // Arterioscler. Thromb. Vascular. Biol. –2004. – 24. – P.2227–2235.
  20. 19. Stollenwerk M., Schiopu A., Fredrikson G. et al. Very low density lipoprotein potentiates tumor necrosis factor-a expression in macrophages // Atherosclerosis. –2005. – 179, № 2. – P.247–254.
  21. 20. Suganami T., Nishida J., Ogawa Y. A paracrine loop between adipocytes and macrophages aggravates inflammatory changes. Role of free fatty acids and tumor necrosis factor-a // Arterioscler. Thromb. Vas-cular. Biol. – 2005. – 25. – P.2062–2071.
  22. Tripathy D., Mohanty P., Dhindsa S. et al. Elevation of free fatty acids induces inflammation and impairs vascular reactivity in healthy subjects // Diabetes. –2003. – 52. – P.2882–2887.

© National Academy of Sciences of Ukraine, Bogomoletz Institute of Physiology, 2014-2019.