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ISSN 2522-9028 (Print)
ISSN 2522-9036 (Online)

Fiziologichnyi Zhurnal

is a scientific journal issued by the

Bogomoletz Institute of Physiology
National Academy of Sciences of Ukraine

Editor-in-chief: V.F. Sagach

The journal was founded in 1955 as
1955 – 1977 "Fiziolohichnyi zhurnal" (ISSN 0015 – 3311)
1978 – 1993 "Fiziologicheskii zhurnal" (ISSN 0201 – 8489)
1994 – 2016 "Fiziolohichnyi zhurnal" (ISSN 0201 – 8489)
2017 – "Fiziolohichnyi zhurnal" (ISSN 2522-9028)

Fiziol. Zh. 2008; 54(3): 36-46

The presence and character of interrelations between lipid metabolism disturbances andsystemic inflammation

V.V.Ambroskina, T.А.Kriachok, A.P.Larionov, T.V.Talaeva, V.V.Bratus.

    NSC N.D. Strazhesko Institute of Cardiology”, UkrainianAcademy of Medical Sciences, Kyiv


The aim of the investigation was to determine the existence and describe interconnection between the lipid metabolism disturbances and development of systemic inflammation. The work was carried out on rabbits in two series of experiments: in the first one, the model of inflammation was reproduced be means of intravenous injection of bacterial lipopolysaccharide. In the second one, the model of lipid disturbances induced by lipids enriched diet was reproduced. In both series of experi- ments, the indexes of inflammation and oxidative stress inten- sity, metabolism of lipids and lipoproteins, insulin sensitivity, blood lipoprotein proatherogenic and immunogenic modifica- tion were determined. The data obtained confirmed the exist- ence of distinct direct links between investigated influences: during the primary induced inflammation we observed pro- nounced disturbances in lipid and lipoprotein metabolism, while under the primary induction of lipid disturbances the systemic inflammation and oxidative stress were developed. The connection between the action of both influences was greatly mediated by their ability to induce insulin resistance. There was also shown that the interrelation between these factors is the cause of blood lipoprotein proatherogenic and immunogenic modification, which is the main effector mecha- nism of atherosclerosis development and progression.


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© National Academy of Sciences of Ukraine, Bogomoletz Institute of Physiology, 2014-2024.