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ISSN 2522-9028 (Print)
ISSN 2522-9036 (Online)
DOI: https://doi.org/10.15407/fz

Fiziologichnyi Zhurnal

is a scientific journal issued by the

Bogomoletz Institute of Physiology
National Academy of Sciences of Ukraine

Editor: V.F. Sagach

The journal was founded in 1955 as
1955 – 1977 "Fiziolohichnyi zhurnal" (ISSN 0015 – 3311)
1978 – 1993 "Fiziologicheskii zhurnal" (ISSN 0201 – 8489)
1994 – 2016 "Fiziolohichnyi zhurnal" (ISSN 0201 – 8489)
2017 – "Fiziolohichnyi zhurnal" (ISSN 2522-9028)

Fiziol. Zh. 2000; 46(6): 54-60


Modulation of k[sub]atp[/sub] channel activity in normotensiveand hypertensive animals

R. B. Strutinskii, A. A. Moibenko

    A.A.Bogomoletz Institute of PhysiologyNational Academy of Science of Ukraine, Kiev


Abstract

It was shown that vasodilatory effects of ATP-sensitive potassium channels opener — flocalin — depend from character of increase of initial vessel tone. Norepinephrine and angiotensin II partially inhibit effects of flocalin, thus they depressed of KATP channel activity. The inhibitory effect of angiotensin II increases under arterial hypertension conditions. It was shown that vasodilatory effects of flocalin significantly do not distingnish in experiments on normotensive and hypertensive rats under K+-depolarization conditions. While the vasodilatory effects acetylcholine on hyper- tensive rats are significantly diminished. These data suggests that flocalin could be a perspective substance for treatment of hypertension.

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