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ISSN 2522-9028 (Print)
ISSN 2522-9036 (Online)

Fiziologichnyi Zhurnal

is a scientific journal issued by the

Bogomoletz Institute of Physiology
National Academy of Sciences of Ukraine

Editor-in-chief: V.F. Sagach

The journal was founded in 1955 as
1955 – 1977 "Fiziolohichnyi zhurnal" (ISSN 0015 – 3311)
1978 – 1993 "Fiziologicheskii zhurnal" (ISSN 0201 – 8489)
1994 – 2016 "Fiziolohichnyi zhurnal" (ISSN 0201 – 8489)
2017 – "Fiziolohichnyi zhurnal" (ISSN 2522-9028)

Fiziol. Zh. 2008; 54(2): 82-89

The stress generatedpotential in rats. femur at the different modes of mechanical loading

O.M. Levashov, B.A. Berezovskii, M.I. Levashov, S.L. Saphonov.

    Ин-т физиологии им. А.А. Богомольца НАН Украины, Киев


It was studied the stress generated potential (SGP) of moist femur bones of 24 Vistar rats-males in normo- and hypokine- sia conditions. The mechanical loading on bone was evened 30-50 and 100% from animal body mass. The mechanical pres- sure was carried out in axial direction. The rats stay in hard hypokinesia for 28 days. In all experiments Ag-AgCl with a salt bridge from 0,9% NaCl in 2% agar were utilized (Cоchran G.V. et al., 1989). It was set that amplitude of electric poten- tial which arises up in bones at the mechanical loading depends on the level of this loading. However there is a certain opti- mum of the mechanical loading which provides the maximal increase of SGP. This optimum is in the range of physiology level of loadings. At development of hypokinetic osteopenia SGP diminished most substantially in the range of physiology level loadings also. It may be one of reasons of low efficiency of the physical loadings at development age-old osteopenia and slow renewal of bone tissue after hypokinesia.


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