The stress generatedpotential in rats. femur at the different modes of mechanical loading
O.M. Levashov, B.A. Berezovskii, M.I. Levashov, S.L. Saphonov.
Ин-т физиологии им. А.А. Богомольца НАН Украины, Киев
It was studied the stress generated potential (SGP) of moist
femur bones of 24 Vistar rats-males in normo- and hypokine-
sia conditions. The mechanical loading on bone was evened
30-50 and 100% from animal body mass. The mechanical pres-
sure was carried out in axial direction. The rats stay in hard
hypokinesia for 28 days. In all experiments Ag-AgCl with a
salt bridge from 0,9% NaCl in 2% agar were utilized (Cоchran
G.V. et al., 1989). It was set that amplitude of electric poten-
tial which arises up in bones at the mechanical loading depends
on the level of this loading. However there is a certain opti-
mum of the mechanical loading which provides the maximal
increase of SGP. This optimum is in the range of physiology
level of loadings. At development of hypokinetic osteopenia
SGP diminished most substantially in the range of physiology
level loadings also. It may be one of reasons of low efficiency
of the physical loadings at development age-old osteopenia
and slow renewal of bone tissue after hypokinesia.
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