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ISSN 2522-9028 (Print)
ISSN 2522-9036 (Online)
DOI: https://doi.org/10.15407/fz

Fiziologichnyi Zhurnal

is a scientific journal issued by the

Bogomoletz Institute of Physiology
National Academy of Sciences of Ukraine

Editor-in-chief: V.F. Sagach

The journal was founded in 1955 as
1955 – 1977 "Fiziolohichnyi zhurnal" (ISSN 0015 – 3311)
1978 – 1993 "Fiziologicheskii zhurnal" (ISSN 0201 – 8489)
1994 – 2016 "Fiziolohichnyi zhurnal" (ISSN 0201 – 8489)
2017 – "Fiziolohichnyi zhurnal" (ISSN 2522-9028)

Fiziol. Zh. 2008; 54(2): 75-81


The gaseous exchange,thermoregulation and antioxidant enzyme activities in aging c57bl/6 mice

N.A. Utko, I.N.pishel, V.V. Bezrukov, KH.K. MuradiaN.

    Ін-т геронтології АМН України


Abstract

The distribution type and correlative links between physi- ological and biochemical indices characterizing functional con- dition of the systems of gaseous exchange (Vo2 and Vco2), thermoregulation (body temperature and coefficient of thermoconductivity) and antioxidant defense have been stud- ied in 62 young (3-5mo.) and 58 old (23-26 mo.) male C57Bl/ 6 mice. The coefficients of variation differed significantly de- pending on the variable but not the age-group. Mean values of Vo 2 and Vco2, body temperature and thermoconductivity, but not activities of the antioxidant enzymes, declined in aging. Moreover, the activities of catalase, glutathione-peroxidase and glutathionereductase, i.e. enzymes involved in regulation of hydrogen peroxide level, increased in aging. The correlations between Vo2 and Vco2, Vo2 and body temperature or Vo2 and the liver pH, as well as between the antioxidant enzyme activi- ties exhibited little age-changes. However, three-dimensional non-linear models revealed significant age-changes in relations between the studied variables

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