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ISSN 2522-9028 (Print)
ISSN 2522-9036 (Online)
DOI: https://doi.org/10.15407/fz

Fiziologichnyi Zhurnal

is a scientific journal issued by the

Bogomoletz Institute of Physiology
National Academy of Sciences of Ukraine

Editor-in-chief: V.F. Sagach

The journal was founded in 1955 as
1955 – 1977 "Fiziolohichnyi zhurnal" (ISSN 0015 – 3311)
1978 – 1993 "Fiziologicheskii zhurnal" (ISSN 0201 – 8489)
1994 – 2016 "Fiziolohichnyi zhurnal" (ISSN 0201 – 8489)
2017 – "Fiziolohichnyi zhurnal" (ISSN 2522-9028)

Fiziol. Zh. 2007; 53(6): 67-72


State of intracellular signaling systems under endothelialdysfunction

М.E. Barinova, О.N. Sulayeva.



Abstract

To estimate the state of different parts of intracellular signaling system associated with NO production after a2-adrenoreceptors stimulation under endothelial dysfunction in 22 patients with dia- betic foot, the inhibitory analysis of clophelin-induced platelets aggregation modulation by administration of eNOS stimulator (L-arginin) and inhibitor (L-NAME), modulator of Са- calmoduline (triphtazine), guanilate cyclase stimulator (sodium nitroprusside), inhibitors of phosphodiesterases (theophillinum) and protein kinase А (butamide). It was shown that endothelial dysfunction in patients with diabetic foot is associated with al- teration of adrenoreactivity and inhibition of eNOS, guanilate cyclase, protein kinase A and stimulation of phosphodiesterases activity.

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© National Academy of Sciences of Ukraine, Bogomoletz Institute of Physiology, 2014-2019.