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ISSN 2522-9028 (Print)
ISSN 2522-9036 (Online)
DOI: https://doi.org/10.15407/fz

Fiziologichnyi Zhurnal

is a scientific journal issued by the

Bogomoletz Institute of Physiology
National Academy of Sciences of Ukraine

Editor-in-chief: V.F. Sagach

The journal was founded in 1955 as
1955 – 1977 "Fiziolohichnyi zhurnal" (ISSN 0015 – 3311)
1978 – 1993 "Fiziologicheskii zhurnal" (ISSN 0201 – 8489)
1994 – 2016 "Fiziolohichnyi zhurnal" (ISSN 0201 – 8489)
2017 – "Fiziolohichnyi zhurnal" (ISSN 2522-9028)

Fiziol. Zh. 2007; 53(6): 46-51


Influence of mitogen-activated protein kinases and transcriptional factor c-Fos on estradiol signal transduction in the rat adrenocorticocytes

O.I. Kovzun.



Abstract

Signal transduction mechanisms mediating estradiol regulatory signals in the adrenal cortex were studied in rats. The effect of estradiol benzoate treatment on corticosteroids secretion, levels of ERK1/2, JNK, p38 mitogen-activated protein kinases, tran- scription factors с-Jun and с-Fos in adrenal cortex were investigated. The level of ERK1/2 was increased 1.7-fold in adrenocortical tissue after injections (3 days, 100 mkg per rat) of estradiol. However, the level of p38 kinase and protein kinase JNK was not changed in these conditions. The tran- scription factor AP-1, which includes c-Fos and c-Jun factors, is involved in realization of estradiol signal transduction. The level of c-Fos protein raised 1.8-fold after estradiol treatment, c-Jun protein was not increased. We conclude that ERK1/2 kinase and transcriptional factor c-Fos mediate fast estrogen signal transduction in adrenocorticocytes

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