The significance ofhyperlipidemia and decrease of lipid tolerance as the factors of atherogenesis
V.V.Ambroskina, T.А.Kriachok, O.P.Larionov, T.V.Talaeva, V.V.Bratus.
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Abstract
In experiments performed on rabbits the influence of acute and
chronic alimentary lipid loading on the pathogenic factors of
atherosclerosis was examined. A single moderate lipid loading
even in normal rabbits was established to induce a transitory
development of the proatherogenic changes, which includes
appearance of dislipidemia of diabetic type, activation of sys-
temic inflammation and free radical reactions, blood lipoprotein
modification. Prolonged keeping of rabbits on the diet enriched
with lipids induced the development of complex changes which
are typical for insulin resistance with specific lipid and
lipoprotein metabolism disturbances, increased plasma athero-
genic potential, activation of systemic inflammation and oxi-
dative stress. We also noticed a sharp decrease of lipid toler-
ance and acute lipid loading was accompanied by more pro-
nounced changes than in normal rabbits. The data show that
the excessive consumption of alimentary lipids can induce the
development and sharp activation of atherosclerosis patho-
genic factors.
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