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ISSN 2522-9028 (Print)
ISSN 2522-9036 (Online)
DOI: https://doi.org/10.15407/fz

Fiziologichnyi Zhurnal

is a scientific journal issued by the

Bogomoletz Institute of Physiology
National Academy of Sciences of Ukraine

Editor-in-chief: V.F. Sagach

The journal was founded in 1955 as
1955 – 1977 "Fiziolohichnyi zhurnal" (ISSN 0015 – 3311)
1978 – 1993 "Fiziologicheskii zhurnal" (ISSN 0201 – 8489)
1994 – 2016 "Fiziolohichnyi zhurnal" (ISSN 0201 – 8489)
2017 – "Fiziolohichnyi zhurnal" (ISSN 2522-9028)

Fiziol. Zh. 2007; 53(6): 19-28

The significance ofhyperlipidemia and decrease of lipid tolerance as the factors of atherogenesis

V.V.Ambroskina, T.А.Kriachok, O.P.Larionov, T.V.Talaeva, V.V.Bratus.




Abstract

In experiments performed on rabbits the influence of acute and chronic alimentary lipid loading on the pathogenic factors of atherosclerosis was examined. A single moderate lipid loading even in normal rabbits was established to induce a transitory development of the proatherogenic changes, which includes appearance of dislipidemia of diabetic type, activation of sys- temic inflammation and free radical reactions, blood lipoprotein modification. Prolonged keeping of rabbits on the diet enriched with lipids induced the development of complex changes which are typical for insulin resistance with specific lipid and lipoprotein metabolism disturbances, increased plasma athero- genic potential, activation of systemic inflammation and oxi- dative stress. We also noticed a sharp decrease of lipid toler- ance and acute lipid loading was accompanied by more pro- nounced changes than in normal rabbits. The data show that the excessive consumption of alimentary lipids can induce the development and sharp activation of atherosclerosis patho- genic factors.

Full text: (PDF, in Ukrainian)

References

  1. Аронов Д.М. Лечение и профилактика атеро- склероза. – М.:Триада, Х.2000. – 411 с.
  2. Талаева Т.В., Корниенко О.В., Братусь В.В. и др. Атерогенная модификация липопротеинов крови и гиперхолестеринемия как следствия острого воспалительного процесса // Журн. АМН Украины. – 1997. – 3, № 3. – С.463–471.
  3. Тертов В.В, Каленич О.С., Орехов А.Н. Перито- неальные макрофаги как модель для изучения атерогенного потенциала плазмы крови // Кардио- логия. – 1990. – №10. – С.30–31.
  4. Adiels M., Borйn J., Caslake M.J. et al. Overproduc- tion of VLDL 1 driven by hуperglycemia is a dominant feature of diabetic dyslipidemia // Arterioscler. Thromb. Vascular. Biol. – 2005. – 25. – P.11697–1705.
  5. Bays H. Atherogenic dyslipidaemia in type 2 diabetes and metabolic syndrome: current and future treatment options // Brit. J.Diabetes. Vascular. Dis. – 2003. – 3, № 5. – P.356–360.
  6. Berg A.H., Lin Y., Lisanti M.P., Scherer P.E. Adipocyte differentiation induces dynamic changes in NF-kB expression and activity // Amer. J. Physiol. Endocrinol. and Metabol. – 2004. – 287. – P.E1178–E1188.
  7. Broom I. Thinking around abdominal obesity and cardiovascular risk // Brit. J. Diabetes Vascular. Dis. – 2006. – 6, № 2. – P.58–61.
  8. Chirieac D.V., Collins H.L., Cianci J.et al. Altered triglyceride-rich lipoprotein production in Zucker diabetic fatty rats // Amer. J.Physiol. Endocrinol. and Metabol. – 2004. – 287. – P.E42–E49.
  9. 9. De Ciuceis C., Amiri F., Brassard P. et al. Reduced vascular remodeling, endothelial dysfunction, and oxi- dative stress in resistance arteries of angiotensin II– infused macrophage colony-stimulating factor-deficient mice. Evidence for a role in inflammation in angiotensin- induced vascular injury // Arterioscler. Thromb. Vas- cular. Biol. – 2005. – 25. – P.2106–2114.
  10. 10. Esposito K., Giugliano D. Diet and inflammation: a link to metabolicand cardiovascular diseases // Europ. Heart J. – 2006. – 27, № 1. – P.15–20.
  11. Giannattasio C., Zoppo A., Gentile G.et al. Acute effect of high-fat meal on endothelial function in moderately dyslipidemic subjects // Arterioscler. Thromb.Vascular. Biol. – 2005. – 25. – P.406–412.
  12. Halle M., Berg A., Baumstark M.W. et al. Influence of mild to moderately elevated triglycerides on low density lipoprotein subfraction concentration and composition in health men with low density lipoprotein cholesterol levels // Atherosclerosis. – 1999. – 143. – P.185–192.
  13. Karpe F., Boquist S., Tang R.et al. Remnant lipopro- teins are related to intima-media thickness of the carotid artery independently of LDL cholesterol and plasma triglycerides // J.Lipid. Res. – 2001. – 42. – P.17–21.
  14. Klein S. The case of visceral fat: argument for the defense // J.Clin.Invest. – 2004. – 113. – P.1530–1532.
  15. Natarajan R., Nadler J.L. Lipid inflammatory mediators in diabetic vascular disease // Аrterioscl. Thromb. Vascular. Biol. – 2004. – 24. – P.1542–1548.
  16. Ritchie S.A., Ewart M.A., Perry C.G. et al. The role of insulin and the adipocytokines in regulation of vascular endothelial function // Clin. Sci. (London). – 2004. – 107. – P.519–532.
  17. Rivellese A.A., De Natale C., Di Marino L. et al. Exogenous and endogenous postprandial lipid abnormalities in type 2 diabetic patients with optimal blood glucose control and optimal fasting triglyceride levels // J.Clin. Endocrinol. and Metabol. – 2004. – 89, № 5. – P. 2153–2159.
  18. Stern M.P. Diabetes and cardiovascular disease. The «common soil» hypothesis // Diabetes. – 1995. – 44. – P.369–374.
  19. 19. Valabhji J., Elkeles R.S. Dyslipidemia in type 2 diabe- tes: epidemiology and biochemistry // Brit. J.Diabetes Vascular. Dis. – 2003. – 3, № 3. – P.184–189.
  20. 20. Wang C.C.L., Goalstone M.L., Draznin B. Molecular mechanisms of insulin resistance that impact cardiovascular biology // Diabetes. – 2004. – 53, № 11. – P.2735–2740.
  21. Wilson PWF. Diabetes mellitus and coronary heart dis- ease // Endocrinol. and Metab. Clin. – 2001. – 30. – P.857–881.
  22. York D.A., Rossner S., Caterson I. et al. Obesity, a worldwide epidemic related to heart disease and stroke group I: worldwide demographics of obesity // Circulation. – 2004. – 110. – P.463–470.
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