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ISSN 2522-9028 (Print)
ISSN 2522-9036 (Online)
DOI: https://doi.org/10.15407/fz

Fiziologichnyi Zhurnal

is a scientific journal issued by the

Bogomoletz Institute of Physiology
National Academy of Sciences of Ukraine

Editor-in-chief: V.F. Sagach

The journal was founded in 1955 as
1955 – 1977 "Fiziolohichnyi zhurnal" (ISSN 0015 – 3311)
1978 – 1993 "Fiziologicheskii zhurnal" (ISSN 0201 – 8489)
1994 – 2016 "Fiziolohichnyi zhurnal" (ISSN 0201 – 8489)
2017 – "Fiziolohichnyi zhurnal" (ISSN 2522-9028)

Fiziol. Zh. 2007; 53(6): 19-28


The significance ofhyperlipidemia and decrease of lipid tolerance as the factors of atherogenesis

V.V.Ambroskina, T.А.Kriachok, O.P.Larionov, T.V.Talaeva, V.V.Bratus.



Abstract

In experiments performed on rabbits the influence of acute and chronic alimentary lipid loading on the pathogenic factors of atherosclerosis was examined. A single moderate lipid loading even in normal rabbits was established to induce a transitory development of the proatherogenic changes, which includes appearance of dislipidemia of diabetic type, activation of sys- temic inflammation and free radical reactions, blood lipoprotein modification. Prolonged keeping of rabbits on the diet enriched with lipids induced the development of complex changes which are typical for insulin resistance with specific lipid and lipoprotein metabolism disturbances, increased plasma athero- genic potential, activation of systemic inflammation and oxi- dative stress. We also noticed a sharp decrease of lipid toler- ance and acute lipid loading was accompanied by more pro- nounced changes than in normal rabbits. The data show that the excessive consumption of alimentary lipids can induce the development and sharp activation of atherosclerosis patho- genic factors.

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