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Periodic motor-secretor activity of stomach indisbalance of its regulatory mechanisms
O.S. Trushenko, O.B. Murzin, A. I. Rudenko
Institute of Gastroenterology of AMS of UkraineDnipropetrovs.k National University
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Abstract
The periodic gastric motor-and-secretor activity in modeling of
disbalance of autonomic nervous regulation in chronic fistula
canine experiments was studied. It was found that autonomic
nervous disbalance at the first stages was accompanied with
reorganization of periodic gastric motor and secretor phase
lengths which resulted in shortening of gastric basic myoelectri-
cal rhythm period (BMRP), appearing of gastric acid secretion
in fasted state and increasing of secretor response to exog-
enous histamine stimulation. Indeed, the gastric motor rhythms
appeared to be more sensitive to changes in activity of regulatory
mechanisms than the functional activity of the gastric secretor
glands. Long-term disbalance of regulatory mechanisms caused
the “regulatory rejection”, which was associated with increas-
ing of duodenogastric reflux and increasing of gastric BMRP,
as well as with decreasing of gastric mucosal defending prop-
erties. We hypothesize that nonadrenergic noncholinergic path-
way may play a role in reorganization of the observed gastric
motor-and-secretor activity.
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