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ISSN 2522-9028 (Print)
ISSN 2522-9036 (Online)
DOI: https://doi.org/10.15407/fz

Fiziologichnyi Zhurnal

is a scientific journal issued by the

Bogomoletz Institute of Physiology
National Academy of Sciences of Ukraine

Editor-in-chief: V.F. Sagach

The journal was founded in 1955 as
1955 – 1977 "Fiziolohichnyi zhurnal" (ISSN 0015 – 3311)
1978 – 1993 "Fiziologicheskii zhurnal" (ISSN 0201 – 8489)
1994 – 2016 "Fiziolohichnyi zhurnal" (ISSN 0201 – 8489)
2017 – "Fiziolohichnyi zhurnal" (ISSN 2522-9028)

Fiziol. Zh. 2007; 53(5): 91-98


Periodic motor-secretor activity of stomach indisbalance of its regulatory mechanisms

O.S. Trushenko, O.B. Murzin, A. I. Rudenko

    Institute of Gastroenterology of AMS of UkraineDnipropetrovs.k National University


Abstract

The periodic gastric motor-and-secretor activity in modeling of disbalance of autonomic nervous regulation in chronic fistula canine experiments was studied. It was found that autonomic nervous disbalance at the first stages was accompanied with reorganization of periodic gastric motor and secretor phase lengths which resulted in shortening of gastric basic myoelectri- cal rhythm period (BMRP), appearing of gastric acid secretion in fasted state and increasing of secretor response to exog- enous histamine stimulation. Indeed, the gastric motor rhythms appeared to be more sensitive to changes in activity of regulatory mechanisms than the functional activity of the gastric secretor glands. Long-term disbalance of regulatory mechanisms caused the “regulatory rejection”, which was associated with increas- ing of duodenogastric reflux and increasing of gastric BMRP, as well as with decreasing of gastric mucosal defending prop- erties. We hypothesize that nonadrenergic noncholinergic path- way may play a role in reorganization of the observed gastric motor-and-secretor activity.

References

  1. Руденко А.І., Майкова Т.В., Мосійчук Л.М. та ін. Клініко-лабораторна оцінка функціонального стану секреторних залоз шлунка (методичні рекомендації). – К., 2004. – 23 с.
  2. Руденко А.І., Трушенко О.С., Мурзін О.Б. Періодична діяльність секреторних залоз шлунка при вираз- ковому ушкодженні гастродуоденальної зони // Вісн. Дніпропетров. ун-ту. Серія: Біологія. Екологія. – 2006. – Вип. 14. – Т. 1. – С. 154–159.
  3. А. с. 1475599 (СССР) МКИ А 61 В 10/00- Способ определения состояния нервной регуляции желу- дочной секреции / Руденко А.И., Крышень В. П. (СССР). З-ка № 4024896/28 – 4 Заявл. 20.02.86. Опубл.15.05.89. Бюл. № 6. – 14 с.
  4. Западнюк В.П., Западнюк В.И., Захария Е.А. Лабораторные животные, их разведение, содержание и использование в эксперименте. – К.: Вища школа, 1984. – 326 с.
  5. Овсянников В.Н. Интегративные механизмы форми- рования моторных эффектов тонкой кишки // Рос. физиол. журн. им И.М. Сеченова. – 1999. – 85, № 9–10. – С. 1278–1289.
  6. Петри А., Сэбин К. Наглядная статистика в медицине. – М.: ГЕОТАР-МЕД. – 2003. – 143 с.
  7. Подлетняя Е.А., Мамчур В.И. Механизмы гастро- дуоденотоксичности нестероидных противовоспа- лительных средств // Журн. АМН України. – 2005. – 11, № 1. – С. 47–62.
  8. Смирнов В.М., Лычкова А.Э. Механизмы синергизма между отделами вегетативной нервной системы в регуляции моторики желудка и сфинктера Одди // Бюл. эксперим. биологии и медицины. – 2003. – 135, № 4. – С. 382–385.
  9. 9. Acid related diseases (Biology and Treatment) / Modlin I.M., Sachs G. – Schnetzor-Verlad GmbHD-Konstanz, 1998. – 368 p.
  10. 10. Boeckxstaens G.E., Pelckmans P.A., De Man J.G. et al. Evidence for a differential release of nitric oxide and vasoactive intestinal polypeptide by non-adrenergic non- cholinergic nerves in the rat gastric fundus // Arch. Int. Pharmacodyn. – 1992. – 318. – P. 107–115.
  11. Gastrointestinal Pharmacology and Therapeutics / G. Friedman, E.D. Jacobson, R.W. McCallum. – N.Y.: Lippincott-Raven, 1997. – 1164 p.
  12. Chiloiro M., Russo F., Riezzo G. et al. Effect of Helicobacter pylori infection on gastric emptying and gastrointestinal hormones in dyspeptic and healthy subjects // Dig. Dis. Sci. – 2001. – 46, № 1. – P. 46–53.
  13. Commission of the European Communities. Council Directive of 24 November 1988 on the approximation of laws, regulations and administrative provisions of the Member States regarding the protection of animals used for experimental and other scientific purposes. 1986. 86/609/EEC). ISSD 03780 6978.
  14. Dalenbдck J., Abrahamson H., Bjцrnson E. Human duodenogastric reflux, retroperistalsis, and MMC // Amer. J. Physiol. – 1998. – 275. – P. R762–R769.
  15. D’amato M., Curro D., Montuschi P. Evidence for dual components in the non-adrenergic non-cholinergic relaxation in the rat gastric fundus: role of endogenous nitric oxide and vasoactive intestinal polypeptide // J. Auton. Nerv. Syst. – 1992. – 37. – P. 175–186.
  16. Meulemans A.L., Eelen J.G., Schuurkes J.A. NO me- diates gastric relaxation after brief vagal stimulation in anesthetized dogs // Amer. J. Physiol. – 1995. – Vol. 269. – P. G255–G261.
  17. Tanaka T., Kendrick M.L., Zyromski N.J. et al. Vagal innervation modulates motor pattern but not initiation of canine gastric migrating motor complex // Amer. J. Physiol. Gastrointest. Liver Physiol. – 2001. – 281. – P. G283–G292.

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