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ISSN 2522-9028 (Print)
ISSN 2522-9036 (Online)
DOI: https://doi.org/10.15407/fz

Fiziologichnyi Zhurnal

is a scientific journal issued by the

Bogomoletz Institute of Physiology
National Academy of Sciences of Ukraine

Editor-in-chief: V.F. Sagach

The journal was founded in 1955 as
1955 – 1977 "Fiziolohichnyi zhurnal" (ISSN 0015 – 3311)
1978 – 1993 "Fiziologicheskii zhurnal" (ISSN 0201 – 8489)
1994 – 2016 "Fiziolohichnyi zhurnal" (ISSN 0201 – 8489)
2017 – "Fiziolohichnyi zhurnal" (ISSN 2522-9028)

Fiziol. Zh. 2007; 53(5): 91-98

Periodic motor-secretor activity of stomach indisbalance of its regulatory mechanisms

O.S. Trushenko, O.B. Murzin, A. I. Rudenko

    Institute of Gastroenterology of AMS of UkraineDnipropetrovs.k National University



Abstract

The periodic gastric motor-and-secretor activity in modeling of disbalance of autonomic nervous regulation in chronic fistula canine experiments was studied. It was found that autonomic nervous disbalance at the first stages was accompanied with reorganization of periodic gastric motor and secretor phase lengths which resulted in shortening of gastric basic myoelectri- cal rhythm period (BMRP), appearing of gastric acid secretion in fasted state and increasing of secretor response to exog- enous histamine stimulation. Indeed, the gastric motor rhythms appeared to be more sensitive to changes in activity of regulatory mechanisms than the functional activity of the gastric secretor glands. Long-term disbalance of regulatory mechanisms caused the “regulatory rejection”, which was associated with increas- ing of duodenogastric reflux and increasing of gastric BMRP, as well as with decreasing of gastric mucosal defending prop- erties. We hypothesize that nonadrenergic noncholinergic path- way may play a role in reorganization of the observed gastric motor-and-secretor activity.

Full text: (PDF, in Ukrainian)

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