Changes of nitric oxide system during acutemyocardial ischaemia/reperfusion
A.A. Moibenko, M.Ya. Yuzkiv, A.V. Kotsuruba, A.N. Bukhanevich,L.V. Tumanovska
A.A.Bogomoletz Institute of PhysiologyNational Academy of Science of Ukraine, Kiev;Institute of biochemistry National Academy of Science of Ukraine, Kiev
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Abstract
The reciprocal changes of NOS and arginase activity during acute myocardial ischaemia
(90 min) and reperfusion (180 min) was shown in experiments on chest-closed dogs
with spontaneous breathing. NOS activity in the ischemical injured myocard decreased
on 60 % while arginase activity increased on 487 %. Levels of both alternative pathways
of L-arginine metabolism altered reciprocally too. NO 2–-level was reduced on 57 %,
and urea level increased on 665 %. The same changes were in arterial blood, started
from 10 min of ischamia. These changes can play an important role for development
of acute ischaemia treatment.
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