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ISSN 2522-9028 (Print)
ISSN 2522-9036 (Online)
DOI: https://doi.org/10.15407/fz

Fiziologichnyi Zhurnal

is a scientific journal issued by the

Bogomoletz Institute of Physiology
National Academy of Sciences of Ukraine

Editor-in-chief: V.F. Sagach

The journal was founded in 1955 as
1955 – 1977 "Fiziolohichnyi zhurnal" (ISSN 0015 – 3311)
1978 – 1993 "Fiziologicheskii zhurnal" (ISSN 0201 – 8489)
1994 – 2016 "Fiziolohichnyi zhurnal" (ISSN 0201 – 8489)
2017 – "Fiziolohichnyi zhurnal" (ISSN 2522-9028)

Fiziol. Zh. 2000; 46(6): 3-11


Changes of nitric oxide system during acutemyocardial ischaemia/reperfusion

A.A. Moibenko, M.Ya. Yuzkiv, A.V. Kotsuruba, A.N. Bukhanevich,L.V. Tumanovska

    A.A.Bogomoletz Institute of PhysiologyNational Academy of Science of Ukraine, Kiev;Institute of biochemistry National Academy of Science of Ukraine, Kiev


Abstract

The reciprocal changes of NOS and arginase activity during acute myocardial ischaemia (90 min) and reperfusion (180 min) was shown in experiments on chest-closed dogs with spontaneous breathing. NOS activity in the ischemical injured myocard decreased on 60 % while arginase activity increased on 487 %. Levels of both alternative pathways of L-arginine metabolism altered reciprocally too. NO2-level was reduced on 57 %, and urea level increased on 665 %. The same changes were in arterial blood, started from 10 min of ischamia. These changes can play an important role for development of acute ischaemia treatment.

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