Українська English

ISSN 2522-9028 (Print)
ISSN 2522-9036 (Online)
DOI: https://doi.org/10.15407/fz

Fiziologichnyi Zhurnal

is a scientific journal issued by the

Bogomoletz Institute of Physiology
National Academy of Sciences of Ukraine

Editor-in-chief: V.F. Sagach

The journal was founded in 1955 as
1955 – 1977 "Fiziolohichnyi zhurnal" (ISSN 0015 – 3311)
1978 – 1993 "Fiziologicheskii zhurnal" (ISSN 0201 – 8489)
1994 – 2016 "Fiziolohichnyi zhurnal" (ISSN 0201 – 8489)
2017 – "Fiziolohichnyi zhurnal" (ISSN 2522-9028)

Fiziol. Zh. 2007; 53(3): 78-81


Correction endothelial functiondamaged resulting fromх-irradiation with the help offree and filled liposomes quercetin

O.V. Kislova, А.L. Sapaty, I.G. Kupnovitska,O.O. Moibenko.

    Institute of Pharmacology and Toxicologу Academy ofMedical Sciences of Ukraine, Kyiv;Ivano-Frankovsk State Medical University;A.A.Bogomoletz Institute of Physiology National Academy ofSciences of Ukraine, Kyiv



Abstract

It has been investigation the action of solubil quercetin (corvitin) and quercetin filled liposomes (lipoflavon) on endothelium – dependent г-irradiated isolated rats aortic rings relaxations to acetylcholine. It has been showed, that corvitin addition di- rectly to the buffer solution (0,1 mg/ml) increase endothelium – dependent vascular responses to acetylcholine on 35 %, lipoflavon addition – on 25%.

References

  1. Ковалев В.Б., Ковган В.В., Колчина Е.Ю. Механизмы лечебного действия биофлаваноида кверцетина // Укр. мед. альманах. – 1999. – 2, №4. – С. 176–184.
  2. Мойбенко А.А., Пархоменко А.Н., Кожухов С.Н. Эффективность водорастворимой формы кверце- тина (корвитина) при лечении острого коронарного синдрома с элевацией сегмента ST// Журн. АМН Украины. – 2003. – 9, № 2. – С. 361–370.
  3. Chen C.K., Pace-Asciak C.R. Vasorelaxing activity of resveratrol and quercetinin in isolated rat aorta// Gen.Pharmacol. – 1996. – 27, №2. – P. 363–366.
  4. Olszanecki R., Gebska A., Kozlovski V., Gryglewski R. Flavonoids and nitric oxide synthase// J. Physiol.and Pharmacol. – 2002. – 53, № 4. – P. 571–584.
  5. Shimoi K. Radioprotective effect of antioxidative fla- vonoids in gamma-ray irradiatedmice // Carcinogenesis. – 1994. – 15, № 11. – P. 2669–2672.
  6. Soloviev A. Saline containing phosphatidylcholine liposomes possess the ability to restore endothelial function damaged resulting from G-irradiation // J.Physiol.and Pharmacol. – 2002. – 53, № 4. – P. 701–712.
  7. Soloviev A. Mechanisms of endothelial dysfunction after ionised irradiation: selective impairment of the nitric oxide component of endothelium – dependent vasodi-latation // Brit. J. Pharmacol. – 2003. – 138. – P. 837–844.

© National Academy of Sciences of Ukraine, Bogomoletz Institute of Physiology, 2014-2024.