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ISSN 2522-9028 (Print)
ISSN 2522-9036 (Online)
DOI: https://doi.org/10.15407/fz

Fiziologichnyi Zhurnal

is a scientific journal issued by the

Bogomoletz Institute of Physiology
National Academy of Sciences of Ukraine

Editor-in-chief: V.F. Sagach

The journal was founded in 1955 as
1955 – 1977 "Fiziolohichnyi zhurnal" (ISSN 0015 – 3311)
1978 – 1993 "Fiziologicheskii zhurnal" (ISSN 0201 – 8489)
1994 – 2016 "Fiziolohichnyi zhurnal" (ISSN 0201 – 8489)
2017 – "Fiziolohichnyi zhurnal" (ISSN 2522-9028)

Fiziol. Zh. 2007; 53(3): 23-30


Changes in functioning of colonicepithelium transport system andmucosal morphological indexes inrats with omeprazole-inducedhypergastrinemia of differentlength

T.M.Hurlenko, O.K.Voronina, V.M.Grischuk,G.M.Tolstanova, M.E.Dzerzhins’kiy, T.V.Beregova.

    Kyiv National University named after Taras Shevchenko,Biological Faculty, Kyiv;Peter Bogach Institute of Physiology, Pharmaco-Physiology Department;Kyiv National University named after Taras Shevchenko ,Biological Faculty, Department of Cytology, Histologyand Developmental Biology


Abstract

The role of gastrin in epithelium water and electrolyte (Na+, K+, CI-) transport in comparison with mucosal morphological indexes (crypt depth, thickness of colonic mucosa and epitheliocytes nuclear profound area) was investigated by using of omepra- zole-induced (OM) hypergastrinemia model (for 1-4 weeks) and in vivo perfusing technique in rats. Short-term hypergastrinemia (for 1 – 2 weeks) caused the alterations in electroneutral ab- sorption of NaCl. Prolongation of hypergastrinemia influence up to 3 weeks had entailed the first manifestation of the trophic effect on colonic mucosa expressed in alterations of electro- genic sodium absorption and increased crypt depth with a thick- ened colonic mucosa. Prolonged OM-induced hypergastrinemia (for 4 weeks) had led to decreased colonocytes differentiation level with an increased crypt depth, a thickened colonic mucosa and decreased epitheliocytes nuclear profound area which in turn have provoked the decreasing in net water and NaCl ab- sorption.

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