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ISSN 2522-9028 (Print)
ISSN 2522-9036 (Online)
DOI: https://doi.org/10.15407/fz

Fiziologichnyi Zhurnal

is a scientific journal issued by the

Bogomoletz Institute of Physiology
National Academy of Sciences of Ukraine

Editor-in-chief: V.F. Sagach

The journal was founded in 1955 as
1955 – 1977 "Fiziolohichnyi zhurnal" (ISSN 0015 – 3311)
1978 – 1993 "Fiziologicheskii zhurnal" (ISSN 0201 – 8489)
1994 – 2016 "Fiziolohichnyi zhurnal" (ISSN 0201 – 8489)
2017 – "Fiziolohichnyi zhurnal" (ISSN 2522-9028)

Fiziol. Zh. 2007; 53(3): 9-15


Nuclear ion channels of the granulеcells from the dentate gyrus

O.A. Fedorenko, D.E. Duzhyy , S.M. Marchenko.

    Bogomoletz Institute of Physiology, National Academy ofScience of Ukraine, Kyiv


Abstract

The nuclear envelope is a part of the endoplasmic reticulum which surrounds the genetic apparatus of the cell. Using the patch-clamp technique we have investigated ion channels in the membranes of nuclei isolated from the neurons of the dentate gyrus. Our research has shown that there is anionic (329 рS) on the outer and anionic (157 pS) and cationic (179 рS) channels on the inner nuclear membrane. Ion channels in the nuclear envelope of the neurons of the dentate gyrus differ much from ones of the neurons of the cerebellum and CA1 region of the hippocampus. This fact proves that different types of neurons express different sets of ion channels in the nuclear membranes. The physiological role of the ion nuclear channels in the granule cells is not clear but they may be important for the ion balance between the cytoplasm and the lumen of the nuclear envelope as well as endoplasmic reticulum of the cell if the latter represents an adequate model of granule of the some parts of ER.

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