Nuclear ion channels of the granulеcells from the dentate gyrus
O.A. Fedorenko, D.E. Duzhyy , S.M. Marchenko.
Bogomoletz Institute of Physiology, National Academy ofScience of Ukraine, Kyiv
Abstract
The nuclear envelope is a part of the endoplasmic reticulum
which surrounds the genetic apparatus of the cell. Using the
patch-clamp technique we have investigated ion channels in the
membranes of nuclei isolated from the neurons of the dentate
gyrus. Our research has shown that there is anionic (329 рS) on
the outer and anionic (157 pS) and cationic (179 рS) channels
on the inner nuclear membrane. Ion channels in the nuclear
envelope of the neurons of the dentate gyrus differ much from
ones of the neurons of the cerebellum and CA1 region of the
hippocampus. This fact proves that different types of neurons
express different sets of ion channels in the nuclear membranes.
The physiological role of the ion nuclear channels in the granule
cells is not clear but they may be important for the ion balance
between the cytoplasm and the lumen of the nuclear envelope
as well as endoplasmic reticulum of the cell if the latter represents
an adequate model of granule of the some parts of ER.
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