Modern conception of protein kinasec role in the vascularsmooth muscles tone regulation
I.V. Kizub, O.O. Pavlova, A.I. Solovyov
Institute of Pharmacology and Toxicology Academy ofMedical Sciences of Ukraine, Kyiv
Abstract
Protein kinase C is an important regulatory enzyme that plays
significant role in the vascular tone regulation. Protein kinase C
is involved in the vascular smooth muscle cells (SMC) contrac-
tility at physiological conditions and its hyperreactivity at differ-
ent types of pathology. Myogenic and endothelium-dependent
pathways of protein kinase С-mediated vascular tone regulation
include a variety of cellular mechanisms. The most important
protein kinase C-mediated mechanisms in SMC are the increase
of myophilament Ca 2+-sensitivity; regulation of plasmolema ion
permeability, and proliferative changes in SMC. Protein kinase
C-related mechanisms in vascular endotheliocytes include
regulation of formation and transduction of humoral and electri-
cal signals to SMC that play an important role in the pathologi-
cal vasospasm development.
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