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ISSN 2522-9028 (Print)
ISSN 2522-9036 (Online)
DOI: https://doi.org/10.15407/fz

Fiziologichnyi Zhurnal

is a scientific journal issued by the

Bogomoletz Institute of Physiology
National Academy of Sciences of Ukraine

Editor-in-chief: V.F. Sagach

The journal was founded in 1955 as
1955 – 1977 "Fiziolohichnyi zhurnal" (ISSN 0015 – 3311)
1978 – 1993 "Fiziologicheskii zhurnal" (ISSN 0201 – 8489)
1994 – 2016 "Fiziolohichnyi zhurnal" (ISSN 0201 – 8489)
2017 – "Fiziolohichnyi zhurnal" (ISSN 2522-9028)

Fiziol. Zh. 2007; 53(2): 16-24


Individual features of human adapta-tion to intermittent hypoxia: pos-sible role of hif gene polymorphisms

T.V. Serebrovska, O.V. Korkushko, V.B. Shatilo,E.O. Asanov, V.A. Ischuk, E.V. Moiseenko,T.I. Drevytska, I.M. Mankovska

    O.O. Bogomolets Institute of Physiology, NationalAcademy of Sciences of Ukraine, Kyiv;Institute of Gerontology, AMS of Ukraine, Kyiv


Abstract

The majority of the adaptation processes to hypoxia is based on transcriptional regulation by hypoxia-inducible factors – HIFs. Recently the allele polymorphism of oxygen-dependent deg- radation domain of HIF-1? has been described. It consists in the replacement of cytosine for thymine in 1772 location (С1772 >Т). The physiological significance of such replacement is obscure. In the investigation of 26 healthy elderly subjects (58.5 ± 0.7 yr) we tried to verify whether HIF-1? polymorphism in exon 12 may identify individual features of adaptation to intermit- tent hypoxia training (IHT) (isocapnic hypoxic rebreathing technique, 5-min sessions with 5 min rest intervals, 3 times daily during 10 days). The distribution of HIF-1? genotypes for С1772 >Т were studied by using the polymerase chain reaction and restriction analysis. We detected that all subjects from the group had С/С genotype. Meanwhile, the broad spec- trum of adaptive reactions to IHT was observed, from the best adaptation up to disadaptation. IHT enhanced HVRs in the range of 167% - 5%, blood malon dialdehyde content varied from a decrease by 46% up to an increase by 88%, the changes of superoxide dismutase activity varied from +64% to –56% etc. These results suggest that the С1772 >Т polymorphism in HIF-1? does not contribute to individual peculiarities of ad- aptation to IHT. Because the activity of HIF-1? is regulated by multiple steps including the transcriptional level, the effect of the polymorphism in enother exons on the adaptive reactions remains to be elucidated.

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