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ISSN 2522-9028 (Print)
ISSN 2522-9036 (Online)
DOI: https://doi.org/10.15407/fz

Fiziologichnyi Zhurnal

is a scientific journal issued by the

Bogomoletz Institute of Physiology
National Academy of Sciences of Ukraine

Editor-in-chief: V.F. Sagach

The journal was founded in 1955 as
1955 – 1977 "Fiziolohichnyi zhurnal" (ISSN 0015 – 3311)
1978 – 1993 "Fiziologicheskii zhurnal" (ISSN 0201 – 8489)
1994 – 2016 "Fiziolohichnyi zhurnal" (ISSN 0201 – 8489)
2017 – "Fiziolohichnyi zhurnal" (ISSN 2522-9028)

Fiziol. Zh. 2007; 53(2): 8-15

Genetically determined organ-specific changes of some tissue morphometric characteristics under the various exogenous influences

K V Rozova, T V Trepats'ka, L H Horiana, M H Dubova, I M Man'kovs'ka

    O.O. Bogomolets Institute of Physiology NationalAcademy of Sciences of Ukraine, Kyiv, Ukraine



Abstract

Organ-specific alterations of ultrastructure and morphofunctional condition in different organism's tissues, which could evidence of the genetic factors inclusion under the development of different hypoxic condition in organism, were investigated. The dates obtained indicated the marked organ-specific "structure" reaction of tissues, cells and organelles under various exogenous influences. Such reactions confirm the presence of different genes expression which account for ultrastructure alterations; its activity is determined by a type, intensity, duration of influence as well as organ belonging. Ultrastructural alterations are mainly determined by tissue and cell factors but not by genetically determined system reactions; it is confirmed by various reactions on external factors in animal tissues with different genetically determined oxygen consumption level or genetically determined adaptation to middle-altitude conditions.

Full text: (PDF, in Ukrainian)

References

  1. Березовський В.Я., Ярошенко В.Т. Системна таклінічна реактивність ЦНС до гіпоксії: Огляд //Нейрофізіологія. – 2002. – 34, № 5. – С. 411–418.
  2. Карупу В.Я. Электронная микроскопия. – К.: Вищашкола, 1984. – 208 с.
  3. Меерсон Ф.З., Пшенникова М.Г. Адаптация кстрессорным ситуациям и физическим нагрузкам. –М.: Медицина, 1988. – 256 с.
  4. Портніченко В.І. Два типи енергетичного метабо-лізму у щурів та реакція на гостру гіпоксію за умовактивації калієвих каналів // Клін. та експерим.патологія. – 2004. – ІІІ, № 2, Ч. І. – С. 86–88.
  5. Проблемы гипоксии: молекулярные, физиоло-гические и медицинские аспекты / Под ред.Л.Д.Лукьяновой, И.Бушакова. – М.; Воронеж:Истоки, 2004. – 590 с.
  6. Резников К.М. Общие механизмы формированияответных реакций организма на воздействиефакторов окружающей среды // Прикладныеинформационные аспекты медицины. Сб. научн.работ. – Воронеж, 1998. – Т. 1. – С. 4–9.
  7. Судакова Ю.В., Бакеева Л.Е., Цыпленкова В.Г.Энергозависимые изменения ультраструктурымитохондрий кардиомиоцитов человека при алкого-льном поражении сердца // Архив патологии. – 1999. –№ 2. – С. 15–20.
  8. Судакова Ю.В., Бакеева Л.Е., Цыпленкова В.Г.Деструктивные изменения митохондрий кардио-миоцитов человека при алкогольном поражениисердца // Архив патологии. – 1999. – № 9. – С. 19–23.
  9. 9. Ташке К. Введение в количественную цито-гистологическую морфологию. – Бухарест: Изд-воАСРР, 1980. – 192 с.
  10. 10. Шахламов В.А., Сороковой В.И. Реакция клеток нагипоксию // Архив анатомии, гистологии и эмбрио-логии. – 1983. – 85, № 7. – С. 12–25.
  11. Clarc J.C., Wert S.E., Bachurski C.J. et al. Targeteddisruption of the surfactant protein B gene disrupts sur-factant homeostasis, causing respiratory failure innewborn mice // Proc. Natal. Acad. Sci. USA. – 1995. –92, № 8. – P. 7794–7798.
  12. Denker B. M., Smith B.L., Kuhajda F.P., Agre P. Iden-tification, purification, and partial characterization ofa novel Mr 28,000 integral membrane protein fromerythrocytes and renal tubules // J. Biol. Chem. – 1988. –263, №8. – P. 15634–15642.
  13. Folkesson, H. G., Matthay M.A., Hasegawa H. et al.Transcellular water transport in lung alveolar epithe-lium through mercury-sensitive water channels // Proc.Natl. Acad. Sci. USA. – 1994. – 91, № 4. – P. 4970–4974.
  14. Funaki H., Yamamoto T., Koyama Yu. et al. Localizationand expression of AQP5 in cornea, serous salivaryglands, and pulmonary epithelial cells // Amer. J.Physiol. Cell Physiol. – 1998. – 275, № 4. – P. 1151–1157.
  15. Glumoff V., Vayrynen O., Kangas T., Hallman M. De-gree of lung maturity determines the direction of theinterleukin-1- induced effect on the expression of sur-factant proteins // Amer. J. Respir. Cell Mol. Biol. –2000. – 22, №. 1. – P. 280–288.
  16. Ikegami M., Jobe A.H., Huffman Reed J.A., WhitsettJ.A. Surfactant metabolic consequences of overexpressionof GM-CSF in the epithelium of GM-CSF-deficientmice // Amer. J. Physiol. Lung Cell Mol. Physiol. –1997. – 273, № 6. – P. 709–714.
  17. Kraft C.S., LeMoine C.M., Lyons C.N. et al. Controlof mitochondrial biogenesis during myogenesis // Amer.J. Physiol. Cell Physiol. – 2006. – 290, № 4. – P. 1119–1127.
  18. Lemaire I., Yang H., Lauzon W., Gendron N. M-CSFand GM-CSF promote alveolar macrophage differen-tiation into multinucleated giant cells with distinct phe-notypes // J. Leukoc. Biol. – 1996. – 60, № 3. –P. 509–518.
  19. 19. Marian A.J., Yu Q.-T., Mann D.L. et al. Expression of aMutation Causing Hypertrophic Cardiomyopathy Disrup-tion Sarcomere Assembly in Adult Feline Cardiac Myocytes// Circulat. Res. – 1995. – 77, № 1. – P. 98–106.
  20. 20. Nielsen, S., L. S. King, B. M. Christensen, Agre P.Aquaporins in complex tissues. II. Subcellular distri-bution in respiratory and glandular tissues of rat //Amer. J. Physiol. – 1997. – 273, (Cell Physiol. 42). –P.1549–1561.
  21. Orsini F., Migliacco E., Moroni M. et al. The life spandeterminant p66Shs localizes to mitochondria where itassociated with mitochondrial hear shock protein 70 andregulates trans-membrane potential // J. Biol. Chem. –2004. – 279, № 24. – P. 25689–25695.
  22. Whitsett J.A., Budden A., Hull W.M. et al. Trans-forming growth factor-beta inhibits surfactant proteinA expression in vitro // Biochim. Biophys. Acta. – 1992. –2, № 1123. – P. 257–262.
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