Role of Apoptosisin Pathogenesis of Atherosclerosis
Byts Yu. V., Dosenko V. E., Medvedev V. V.
A.A. Bogomolets National Medical UniversityMinistry of Public Health of Ukraine, Kiev
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Abstract
The recent information about importance of programmed cell death in the development
of atherosclerosis was reviewed. It was emphasized, that intensiveness of apoptosis
was various for smooth muscle cells, macrophages, endothelial cells, lymphocytes,
and changed during the development of such a multistage process as atherosclerosis.
Is was proved, that exactly apoptosis gave specific features to the atherosclerotic
process. The agents inducing atherosclerosis (modified lipoprotein, mechanical
influences, viruses, bacterial toxins, etc.), have unsufficient for initiation of necrosis.
The damage to vascular wall in atherosclerosis is characterized not by intensive influence
of pathogenic factors, but rather constant chronic influence of the agents of moderate
power. Therefore, it is just apoptosis that makes up the critical mechanism of the
reactive-regeneration answer of vascular wall structures to an injure. Evolutionaly,
the apoptic way of the development of answer to an injure appears to be more rational,
as for as it results in minimal losses of cells due to both secondary alteration and
maintenance of fast restoration of the primary cellular architecture of injured tissues
at the expense of the natural mechanisms of regulation of apoptosis and proliferation.
In the certain situation, these positive aspects of apoptosis make up a basis for the
development of a pathology — failures in the program of apoptosis result in chronic
proliferative-degenarative processes, that is in atherosclerosis.
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