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ISSN 2522-9028 (Print)
ISSN 2522-9036 (Online)
DOI: https://doi.org/10.15407/fz

Fiziologichnyi Zhurnal

is a scientific journal issued by the

Bogomoletz Institute of Physiology
National Academy of Sciences of Ukraine

Editor-in-chief: V.F. Sagach

The journal was founded in 1955 as
1955 – 1977 "Fiziolohichnyi zhurnal" (ISSN 0015 – 3311)
1978 – 1993 "Fiziologicheskii zhurnal" (ISSN 0201 – 8489)
1994 – 2016 "Fiziolohichnyi zhurnal" (ISSN 0201 – 8489)
2017 – "Fiziolohichnyi zhurnal" (ISSN 2522-9028)

Fiziol. Zh. 2007; 53(1): 55-61


Characteristics of passiveса2+-transport from myometriumsarcoplasmic reticulum.

Iu.V. Danylovych.

    O.V.Palladin Biochemical Institute NAS of Ukraine, Kyiv


Abstract

With use of model of permeabilizated myocytes from rat uterus and 45Са2+ it is shown, that passive Ca2+ transport from sarco- plasmic reticulum (cation has been preliminary accumulated in ATP-dependent process) is sensitive to 2 mM caffeine, 0,1 mM lidocaine, and also to exogenous Са2+ (it was activated at in- crease in concentration Са2+ from 10-7 up to 10-4 M and was suppressed at 10-3) and рН level (was stimulated by alkalization of medium), along with significant suppression of Mg2+ (0,2 - 4 mM). The analysis of the results received allows us to assume that the model used by us is adequate for studying processes of Са2+ release from sarcoplasmic reticulum, mediated by ryanod- ine receptor channels.

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