The weak acids as protons carriersthrough bilayer lipid membranes
K. Kylyvnyk, G.Ostrovska, L. Khmars’ka,T.Rybalchenko, O. Ksenzek, V.Rybalchenko.
Ukrainian State Chemical Technological University,Dnipropetrovsk, UkraineNational University named after Taras Shevchenko, Kyiv,Ukraine

Abstract
The ability of the weak inorganic acids (H 2S, HCN) and lower
carboxylic acids to interact with bilayer lipid membranes
(BLMs), change their conductivity, act as the protonophores
were investigated. The mechanism of the BLM conductivity
change was studied. The factors affecting the acids interaction
with model lipid membranes were determined. Maximum
conductivity change observes at pH equal dissociation constant
of weak acids and depends on the distribution coefficient
“octanol(membrane)-water”
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