Українська English

ISSN 2522-9028 (Print)
ISSN 2522-9036 (Online)
DOI: https://doi.org/10.15407/fz

Fiziologichnyi Zhurnal

(English title: Physiological Journal)

is a scientific journal issued by the

Bogomoletz Institute of Physiology
National Academy of Sciences of Ukraine

Editor-in-chief: V.F. Sagach

The journal was founded in 1955 as
1955 – 1977 "Fiziolohichnyi zhurnal" (ISSN 0015 – 3311)
1978 – 1993 "Fiziologicheskii zhurnal" (ISSN 0201 – 8489)
1994 – 2016 "Fiziolohichnyi zhurnal" (ISSN 0201 – 8489)
2017 – "Fiziolohichnyi zhurnal" (ISSN 2522-9028)

Fiziol. Zh. 2007; 53(1): 48-54

The weak acids as protons carriersthrough bilayer lipid membranes

K. Kylyvnyk, G.Ostrovska, L. Khmars’ka,T.Rybalchenko, O. Ksenzek, V.Rybalchenko.

    Ukrainian State Chemical Technological University,Dnipropetrovsk, UkraineNational University named after Taras Shevchenko, Kyiv,Ukraine



Abstract

The ability of the weak inorganic acids (H2S, HCN) and lower carboxylic acids to interact with bilayer lipid membranes (BLMs), change their conductivity, act as the protonophores were investigated. The mechanism of the BLM conductivity change was studied. The factors affecting the acids interaction with model lipid membranes were determined. Maximum conductivity change observes at pH equal dissociation constant of weak acids and depends on the distribution coefficient “octanol(membrane)-water”

Full text: (PDF, in Ukrainian)

References

  1. Батлер Дж.Н. Ионные равновесия (математическоеописание) / Пер. с англ. – Л.: Химия, 1973. – 448 с.
  2. Иванов В.Т. Мембраны и ионофоры // Вестник АНСССР. – 1975. – Вып. 6. – С.50–59
  3. Киливник К.Е, Ксенжек О.С. Электрохимическиеметоды исследования модельных липидных мембран//Вопр. химии и хим. технологии. – 2003. №5. –С. 124–130.
  4. Маркин В.С., Чизмаджев Ю.А. Индуцированныйионный транспорт. – М.: Наука, 1974. – 252 c.
  5. Островська Г.В. Первинні механізми мембрано-модулюючої дії біорегуляторів природного ісинтетичного походження: Автореф. дис. …д-рабіол.наук. – К., 2005. – 44 с.
  6. Рыбальченко В.К., Островская Г.В. Мембрано-тропная активность нейрогипофизарных гормонов. –Луганськ, Елтон-2, 1998. – 82 с.
  7. Avdeef A. Absorption and drug development: solubility,permeability, and charge state. – In: Hardcover TradeCloth, John Wiley and Sons, Ltd. (UK), 2003. – 287 p.
  8. Avdeef A. Physicochemical profiling (solubility, per-meability, and charge state) //Curr. Top. Med.Chem. –2001. – 1, № 4. – P.277–351
  9. 9. Cohen F.S., Eisenberg M., McLaughlin S. The kinetic mecha-nism of action of an uncoupler of oxidative phosphorylation// J. Membr.Biol. – 1977. – 37, Dec. – P. 361–396.
  10. 10. David R. L. Handbook of chemistry and physics. 84thEdition. – CRC Press, 2004. – 2475 p.
  11. Finkelstein A. Weak-acid uncouplers of oxidative phos-phorylation. Mechanism of action on thin lipidmembranes// Biochim. and Biophys.Acta–Bioenerget-ics. – 1970. – 205, №1. – P. 1–6.
  12. Goodman B. E. Transport of small molecules acrosscell membranes: water channels and urea transporters //Adv. Physiol. Educ. 2002. – 26, Dec. – P.146–157.
  13. Hansch C., Leo A., Hoekman D. Exploring QSAR:Hydrophobic, Electronic, and Steric Constants. – ACS,Washington, DC, 1995. – 386 р.
  14. Leo A., Hansch C., Elkins D. Chemical partitioncoefficient and their uses // Chem.Rev. – 1971. – 71,№6. – P.526–615.
  15. McLaughlin S. Dilger J.P. Transport of protons acrossmembrane by weak acids // Physiol.Rev. – 1980. – 60,№3. – P. 825–863.
  16. Mueller P., Rudin D.O., Tien H. T., Wescott W. C.Methods for the formation of single bimolecular lipidmembranes in aqueous solution //J. Physiol. Chem. –1963. – 67, №6, – P. 534–535.
  17. Tien H.T., Ottova-Leitmannova A. Planar lipid bilay-ers (BLMs) and their applications. – Elsevier ScienceLtd, 2003. – 1034 p.
  18. Walter A, Gutknecht J. Monocarboxylic acid perme-ation through lipid bilayer membranes // J. Membr.Biol. – 1984. – 77, №3. – P.255–264.
© National Academy of Sciences of Ukraine, Bogomoletz Institute of Physiology, 2014-2025.