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ISSN 2522-9028 (Print)
ISSN 2522-9036 (Online)
DOI: https://doi.org/10.15407/fz

Fiziologichnyi Zhurnal

is a scientific journal issued by the

Bogomoletz Institute of Physiology
National Academy of Sciences of Ukraine

Editor-in-chief: V.F. Sagach

The journal was founded in 1955 as
1955 – 1977 "Fiziolohichnyi zhurnal" (ISSN 0015 – 3311)
1978 – 1993 "Fiziologicheskii zhurnal" (ISSN 0201 – 8489)
1994 – 2016 "Fiziolohichnyi zhurnal" (ISSN 0201 – 8489)
2017 – "Fiziolohichnyi zhurnal" (ISSN 2522-9028)

Fiziol. Zh. 2007; 53(1): 16-23

Distinctive peculiarities of neuronalactivity in nucleus accumbens in sponta-neously hypertensive rats

O.P. Lukhanina, N.O. Pilkevich.

    O.O. Bogomolets Physiology Institute of National Academyof Sciences of Ukraine, Kyiv



Abstract

Spontaneously hypertensive rats (SHR) are generally considered as genetic model both for essential hypertension and attention-deficit hyperactivity syndrome. Neuro- anatomical substrates and mechanisms of neural disorders in the SHR have not been elucidated. This study aimed to deter- mine if the background impulse activity of Nucleus accumbens, core (NAc) neurons and their reactions evoked by amigdala stimulation in the SHR differ from those of normotensive Wistar rats (WR). Besides that we investigated the influence of microiontophoretic beta-adrenergic receptors agonist iso- proterenol administration (5 mM solution; pH 5,0; 10–30 nA) on the NAc neuronal activity. Single unit extracellular recordings were performed under urethane anesthesia. These results showed that percentage of the NAc neurons with bursting discharge pattern of the background impulse activity is signifi- cantly (P<0,001) greater in SHR (42 %) compared to WR (13 %). Also, more of the NAc neurons in the SHR (27 %) had cyclic fluctuations of the frequency of background activity with second period than in the WR (4 %). Excitatory reactions of the NAc neurons evoked by amigdala stimulation in the SHR had more long duration. Activation of beta-adrenergic receptors under isoproterenol administration allows us to reproduce a burst type of neuronal impulsation and cyclic fluctuations of the NAc background neuronal activity in both kinds of animals. Findings obtained support the possibility that in the SHR beta-adrenergic function within the NAc is enhanced compare to control.

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